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BioMed Research International
Volume 2013 (2013), Article ID 902427, 12 pages
http://dx.doi.org/10.1155/2013/902427
Research Article

Effect of Boron Addition on the Thermal, Degradation, and Cytocompatibility Properties of Phosphate-Based Glasses

1Division of Materials, Mechanics and Structures, Faculty of Engineering, University of Nottingham, Nottingham NG7 2RD, UK
2Division of Electrical Systems and Optics, Faculty of Engineering, University of Nottingham, Nottingham NG7 2RD, UK

Received 5 April 2013; Revised 1 July 2013; Accepted 2 July 2013

Academic Editor: Stanley J. Stachelek

Copyright © 2013 Nusrat Sharmin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In this study eight different phosphate-based glass compositions were prepared by melt-quenching: four in the (P2O5)45-(CaO)16- -(MgO)24- system and four in the system (P2O5)50-(CaO)16- -(MgO)24- , where and 10 mol%. The effect of B2O3 addition on the thermal properties, density, molar volume, dissolution rates, and cytocompatibility were studied for both glass systems. Addition of B2O3 increased the glass transition ( ), crystallisation ( ), melting ( ), Liquidus ( ) and dilatometric softening ( ) temperature and molar volume ( ). The thermal expansion coefficient (α) and density ( ) were seen to decrease. An assessment of the thermal stability of the glasses was made in terms of their processing window (crystallisation onset, minus glass transition temperature, ), and an increase in the processing window was observed with increasing B2O3 content. Degradation studies of the glasses revealed that the rates decreased with increasing B2O3 content and a decrease in degradation rates was also observed as the P2O5 content reduced from 50 to 45 mol%. MG63 osteoblast-like cells cultured in direct contact with the glass samples for 14 days revealed comparative data to the positive control for the cell metabolic activity, proliferation, ALP activity, and morphology for glasses containing up to 5 mol% of B2O3.