Clinical Study
Effectiveness of Naltrexone in the Prevention of Delayed Respiratory Arrest in Opioid-Naive Methadone-Intoxicated Patients
Table 5
Comparison of patients’ clinical status during hospitalization.
| Outcome | Total | NLTX | Placebo | P value | | |
| Abnormality | | | | | Loss of consciousness | 10 (18.5%) | 0 (0.0%) | 10 (37.0%) | <0.01* | Bradypnea | 11 (20.4%) | 0 (0.0%) | 11 (40.7%) | <0.01* | Apnea | 5 (9.3%) | 0 (0.0%) | 5 (18.5%) | 0.02* | ABG | | | | | Respiratory acidosis & hypercapnia | 8 (14.8%) | 1 (3.7%) | 7 (25.9%) | 0.05** | Hypoxia | 9 (16.7%) | 1 (3.7%) | 8 (29.6%) | 0.02** | Taking naloxone bolus | 13 (24.1%) | 1 (3.7%) | 12 (44.4%) | <0.01* | Other clinical status | | | | | Naloxone iv Infusion | 10 (18.5%) | 0 (0.0%) | 10 (37.0%) | <0.01* | Need for ICU care | 14 (25.9%) | 0 (0.0%) | 14 (51.9%) | <0.01* | Hospital staying (hrs) | | | | | Mean ± SD | | | | 0.009‡ | Median (range) | 24 (12 to 96) | 20 (14 to 96) | 32 (12 to 96) |
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Based on Chi-Square test. **Based on Fisher’s exact test. ‡Based on Mann-Whitney U test.
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