Table 5: Comparison of patients’ clinical status during hospitalization.

OutcomeTotalNLTXPlaceboP value

Abnormality
 Loss of consciousness10 (18.5%)0 (0.0%)10 (37.0%)<0.01*
 Bradypnea11 (20.4%)0 (0.0%)11 (40.7%)<0.01*
 Apnea5 (9.3%)0 (0.0%)5 (18.5%)0.02*
ABG
 Respiratory acidosis & hypercapnia8 (14.8%)1 (3.7%)7 (25.9%)0.05**
 Hypoxia9 (16.7%)1 (3.7%)8 (29.6%)0.02**
 Taking naloxone bolus13 (24.1%)1 (3.7%)12 (44.4%)<0.01*
Other clinical status
Naloxone iv Infusion10 (18.5%)0 (0.0%)10 (37.0%)<0.01*
Need for ICU care14 (25.9%)0 (0.0%)14 (51.9%)<0.01*
Hospital staying (hrs)
 Mean ± SD 0.009
 Median (range)24 (12 to 96)20 (14 to 96)32 (12 to 96)

Based on Chi-Square test. **Based on Fisher’s exact test. Based on Mann-Whitney U test.