Wound-Healing Potential of Cultured Epidermal Sheets Is Unaltered after Lyophilization: A Preclinical Study in Comparison to Cryopreserved CES

Figure 4

Effects of L-CES on in vivo wound healing in mice compared to F-CES. (a) Wounds observed on days 4, 7, 10, and 14 after wounding. (b) A graph showing the percentage of unhealed area over initial wound size as a function of time for treatment. Statistical significances between F-CES (*𝑃<0.05, 𝑃=0.04) or L-CES (^#𝑃<0.05, 𝑃=0.03) and control were indicated. (c) Masson’s trichrome staining of cross-sectioned biopsies taken from wounds on day 14. Collagen deposition was shown by white arrows. Magnification: ×100, scale bar: 100 μm.

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