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BioMed Research International
Volume 2013 (2013), Article ID 908797, 3 pages
Role of Melanin in Melanocyte Dysregulation of Reactive Oxygen Species
1Oncological Sciences, University of Utah Health Sciences Center, Salt Lake City, UT 84112, USA
2Department of Dermatology, University of Utah Health Sciences Center, Salt Lake City, UT 84112, USA
3Department of Dermatology, Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, UT 84112, USA
Received 3 December 2012; Accepted 25 January 2013
Academic Editor: Norma Possa Marroni
Copyright © 2013 Noah C. Jenkins and Douglas Grossman. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- N. E. Sharpless and R. A. Depinho, “The INK4A/ARF locus and its two gene products,” Current Opinion in Genetics and Development, vol. 9, no. 1, pp. 22–30, 1999.
- D. A. Alcorta, Y. Xiong, D. Phelps, G. Hannon, D. Beach, and J. C. Barrett, “Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts,” Proceedings of the National Academy of Sciences of the United States of America, vol. 93, no. 24, pp. 13742–13747, 1996.
- N. C. Jenkins, T. Liu, P. Cassidy et al., “The p16 INK4A tumor suppressor regulates cellular oxidative stress,” Oncogene, vol. 30, no. 3, pp. 265–274, 2011.
- M. A. Cotter, J. Thomas, P. Cassidy et al., “N-acetylcysteine protects melanocytes against oxidative stress/damage and delays onset of ultraviolet-induced melanoma in mice,” Clinical Cancer Research, vol. 13, no. 19, pp. 5952–5958, 2007.
- K. Urabe, P. Aroca, K. Tsukamoto et al., “The inherent cytotoxicity of melanin precursors: a revision,” Biochimica et Biophysica Acta, vol. 1221, no. 3, pp. 272–278, 1994.
- S. Pavel, F. Van Nieuwpoort, H. Van Der Meulen et al., “Disturbed melanin synthesis and chronic oxidative stress in dysplastic naevi,” European Journal of Cancer, vol. 40, no. 9, pp. 1423–1430, 2004.
- H. T. Wang, B. Choi, and M. S. Tang, “Melanocytes are deficient in repair of oxidative DNA damage and UV-induced photoproducts,” Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 27, pp. 12180–12185, 2010.
- J. A. Recio, F. P. Noonan, H. Takayama et al., “Ink4a/Arf deficiency promotes ultraviolet radiation-induced melanomagenesis,” Cancer Research, vol. 62, no. 22, pp. 6724–6730, 2002.
- P. A. Riley, “Melanin,” International Journal of Biochemistry and Cell Biology, vol. 29, no. 11, pp. 1235–1239, 1997.
- S. R. Wood, M. Berwick, R. D. Ley, R. B. Walter, R. B. Setlow, and G. S. Timmins, “UV causation of melanoma in Xiphophorus is dominated by melanin photosentisized oxidant production,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 11, pp. 4111–4115, 2006.