A Comparison between Use of Spray and Freeze Drying Techniques for Preparation of Solid Self-Microemulsifying Formulation of Valsartan and In Vitro and In Vivo Evaluation

Table 5

Stability studies of liquid and solid SMEF.

Formulation	Evaluation parameters	Observations (months)
		0	1	2	3
L-SMEF (F9)	Physical appearance	Pale yellow clear liquid	Pale yellow clear liquid	Pale yellow clear liquid	Pale yellow clear liquid
	Globule size (nm)	127±16	130±24	132±13	133±32
	Total drug content	100.0±1.4	99.51±0.9	99.50±1.0	99.48±1.2
S-SMSD	Physical appearance	White powder	White powder	White powder	White powder
	Globule size	133±28	135±42	136±24	136±14
	Total drug content	100.0±0.9	99.29±1.2	99.09±1.1	99.02±0.9
S-SMFD	Physical appearance	White powder	White powder	White powder	White powder
	Globule size	160±37	162±23	163±21	165±34
	Total drug content	100.0±0.9	99.10±0.8	99.08±1.3	99.03±1.6