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BioMed Research International
Volume 2013 (2013), Article ID 912413, 9 pages
http://dx.doi.org/10.1155/2013/912413
Research Article

Factors Affecting Graft Survival among Patients Receiving Kidneys from Live Donors: A Single-Center Experience

1Department of Urology , The Urology & Nephrology Center, Mansoura, Egypt
2Division of Nephrology, The Urology & Nephrology Center, Mansoura, Egypt
3Division of Immunology , The Urology & Nephrology Center, Mansoura, Egypt
4Division of Pathology, The Urology & Nephrology Center, Mansoura, Egypt

Received 27 April 2013; Revised 11 June 2013; Accepted 11 June 2013

Academic Editor: Gerald Brandacher

Copyright © 2013 Mohamed A. Ghoneim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. The aim of this report is to study the graft and patient survival in a large cohort of recipients with an analysis of factors that may affect the final outcomes. Methods. Between March 1976 and March 2008, 1967 consecutive live-donor renal transplants were carried out. Various variables that may have an impact on patients and/or graft survival were studied in two steps. Initially, a univariate analysis was carried out. Thereafter, significant variables were embedded in a stepwise regression analysis. Results. The overall graft survival was 86.7% and 65.5%, at 5 and 10 years, respectively. The projected half-life for grafts was 17.5 years and for patients was 22 years. Five factors had an independent negative impact on graft survival: donor's age, genetic considerations, the type of primary immunosuppression, number of acute rejection episodes, and total steroid dose during the first 3 months after transplantation. Conclusions. Despite refinements in tissue matching techniques and improvements in immunosuppression protocols, an important proportion of grafts is still lost following living donor kidney transplantation, presumably due to chronic allograft nephropathy.