Factors Affecting Graft Survival among Patients Receiving Kidneys from Live Donors: A Single-Center Experience

Table 1

(a) Graft survival relative to pretransplantation variables: personal factors. (b) Graft survival relative to pretransplantation variables: hematological factors. (c) Graft survival relative to pre-transplantation variables: immunologic factors. (d) Graft survival relative to pretransplantation variables: current and past medical disorders.

(a)  

	No. of; patients	5-year survival %	95% CI		10-year survival %	95% CI		P-value; (log rank)
Donor’s sex
Male	944	88.6	86.44	90.76	69.9	66.37	73.43	0.012
Female	1023	85.0	82.65	87.35	61.5	57.97	65.03
Donor’s age (years)
≤30	772	87.7	85.35	90.05	68.5	64.58	72.42	<0.001
31–40	627	87.9	85.16	90.64	69.6	65.29	73.91
41–50	389	83.4	79.48	87.32	58.0	52.12	63.88
≥50	179	85.3	79.81	90.79	52.9	43.30	62.50
Recipient’s sex
Male	1466	87.6	85.84	89.46	64.7	54.9	74.50	0.829
Female	501	84.3	80.97	87.63	67.8	63.10	72.50
Recipient’s age (years)
≤20	378	84.4	80.68	88.12	59.0	52.92	65.08	0.002
21–30	709	88.6	86.25	90.95	66.9	62.78	71.02
31–40	556	86.5	83.56	89.44	67.0	62.49	71.51
41–50	270	85.7	81.39	90.01	67.4	60.54	74.26
≥50	54	86.7	75.53	97.87	71.2	52.78	89.62
The sex donor-recipient
Male-male	693	89.5	87.15	91.85	68.2	63.89	72.51	0.082
Male-female	251	86.1	81.59	90.61	74.4	68.13	80.67
Female-male	773	85.9	83.35	88.45	61.5	57.38	65.62
Female-female	250	82.6	77.70	87.50	61.3	54.24	68.36
Donor relationship
Related	1620	87.3	85.54	89.06	65.7	62.96	68.44	0.651
Unrelated	347	84.3	80.18	88.42	64.6	58.33	70.87

(b)   

	No. of; patients	5-year survival %	95% CI		10-year survival %	95% CI		P value; (log rank)
ABO compatibility
Identical	1579	87.3	85.54	89.06	65.8	63.06	68.54	0.500
Different compatible	388	84.5	80.78	88.22	64.4	58.72	70.08
Type of blood transfusion
No transfusion	1049	89.1	87.14	89.80	69.0	65.28	72.72	<0.001
Third party	906	84.2	81.65	83.03	62.8	59.47	66.13
Donor specific	12	—	—		—	—
No. of blood transfusion
No transfusion	1049	89.1	87.14	89.80	68.8	65.08	72.52	0.001
1-2 times	301	87.1	83.18	91.06	67.3	61.42	73.18
3-4	265	82.1	77.40	86.80	64.4	58.13	70.67
≥5	352	83.3	79.18	87.42	57.8	52.31	63.29

(c)  

	No. of; patients	5-year survival %	95% CI		10-year survival %	95% CI		P value; (log rank)
HLA-A, B (class I)
0-MM	153	93.2	89.08	97.32	71.4	62.38	80.42	<0.001
1-MM	229	92.6	89.07	96.13	74.1	67.44	80.76
2-MM	996	86.2	84.04	88.36	62.7	59.17	66.23
3-MM	309	82.5	77.99	87.01	62.4	56.13	68.67
4-MM	132	85.7	79.43	91.97	71.0	62.18	79.82
HLA-DR (class II)
0-MM	201	91.5	87.58	95.42	77.6	69.56	85.64	0.010
1-MM	1720	86.7	84.94	88.46	64.5	61.76	67.24
2-MM	2	—	—		—	—
HLA (class I + II) MM
0-MM	88	94.1	89.0	99.20	79.6	67.84	91.36	0.001
1-MM	102	93.8	89.09	98.50	68.0	57.02	78.98
2-MM	234	90.0	86.08	93.92	71.3	64.64	77.96
3-MM	968	86.2	83.85	88.55	62.8	59.08	66.52
4-MM	290	82.4	77.89	86.91	62.0	55.53	68.47
5-MM	131	85.6	79.33	91.87	69.3	60.28	78.32
HLA-A, B, DR (class I and II) MM
0/1/2	424	91.8	89.06	94.54	72.1	67.00	77.20	0.011
3/4/5/6	1389	85.8	83.44	87.36	63.4	60.46	66.34
Genetic considerations
HLA-ID sibling	152	94.4	92.64	96.16	79.2	70.18	88.22	0.005
1-Haplotype MM (R)	1322	87.7	85.94	89.46	64.7	61.56	67.84
2-Haplotype MM (R + UR)	449	83.2	79.48	86.92	64.0	58.51	69.49

(d)  

	No. of; patients	5-year survival %	95% CI		10-year survival %	95% CI		P value; (log rank)
Bilharziasis
(i) Negative	1442	87.6	85.84	89.36	65.9	62.76	69.04	0.796
(ii) Positive	525	84.6	81.46	87.74	64.4	59.89	68.91
Original kidney diseases
(i) Glomerulonephritis	214	82.8	73.74	88.09	63.5	56.05	70.95	0.020
(ii) Chronic pyelonephritis	259	90.6	86.88	94.32	73.3	67.22	79.38
(iii) Nephrosclerosis	50	84.9	74.51	95.29	55.4	39.72	71.08
(iv) Obstructive uropathy	57	92.2	84.95	99.45	76.0	61.50	90.50
(v) Amyloidosis	33	93.9	85.67	102.13	80.4	64.52	96.28
(vi) Congenital polycystic	51	93.4	86.15	100.65	55.8	37.57	74.03
(vii) Hypoplasia	17	100.0	100.00	100.00	83.1	61.54	104.66
(viii) Others	126	80.9	73.65	88.15	58.8	45.67	71.93
(ix) Not determined	1160	—	—	—	—	—	—
Types of glomerulonephritis (GN)
(i) Mesangiocapillary GN	35	81.8	68.67	94.93	62.7	42.90	82.50	0.701
(ii) Membranous GN	22	57.8	36.83	78.77	57.8	36.83	78.77
(iii) F.S.G.S.	70	90.7	83.64	97.76	66.6	53.66	79.54
(iv) Mesangioproliferative GN	23	73.9	55.87	91.93	67.8	53.66	79.54
(v) Crescentic GN	16	87.5	71.23	103.77	46.7	17.69	75.71
(vi) Hereditary nephritis	48	87.0	77.20	96.80	65.7	49.80	79.60
Pretransplant hypertension
(i) Normotensive	826	87.2	84.85	89.55	64.6	60.48	68.72	0.466
(ii) Hypertensive	1141	86.4	84.24	88.56	66.1	62.77	69.43
No. of transplants received
(i) First	1891	86.0	85.03	88.17	65.1	62.55	67.65	0.242
(ii) Second	73	90.0	82.94	97.06	77.8	67.22	88.38
(iii) Third	3	—	—	—	—	—