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BioMed Research International
Volume 2013 (2013), Article ID 916136, 8 pages
http://dx.doi.org/10.1155/2013/916136
Research Article

Isolation and Characterisation of Mesenchymal Stem Cells from Different Regions of the Human Umbilical Cord

1The Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation Trust & ISTM, Keele University, Oswestry, Shropshire SY10 7AG, UK
2Institute for Orthopaedics, The Robert Jones & Agnes Hunt Orthopaedic Hospital NHS Foundation Trust, Oswestry SY10 7AG, UK

Received 17 April 2013; Accepted 13 June 2013

Academic Editor: Steven Elder

Copyright © 2013 Claire Mennan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Umbilical cords as a source of stem cells are of increasing interest for cell therapies as they present little ethical consideration and are reported to contain immune privileged cells which may be suitable for allogeneic based therapies. Mesenchymal stem cells (MSCs) sourced from several different cord regions, including artery, vein, cord lining, and Wharton’s jelly, are described in the literature. However, no one study has yet isolated and characterised MSCs from all regions of the same cord to determine the most suitable cells for cell based therapeutics.