The Cell Surface GRP78 Facilitates the Invasion of Hepatocellular Carcinoma Cells
Figure 2
Immunoneutralization of the endogenous cell surface GRP78 inhibited the FN induced adhesion and invasion. ((a) and (b)) Transwell analysis of the invasive potential of Mahlavu and SMMC7721 cells treated with the N20 antibody. (Original magnification: 100x.) ((c) and (d)) Cell adhesion analysis of the binding ability of Mahlavu and SMMC7721 cells with the FN-coated substrate when treated with the N20 antibody. Data represent the means ± SD of triplicate determinations in three independent experiments. Asterisks indicate that the differences are statistically significant ( versus iostype IgG treated cells; one-way ANOVA); UT, untreated; IgG goat isotype IgG; N20, the N20 antibody.
