Catecholaminergic Gene Variants: Contribution in ADHD and Associated Comorbid Attributes in the Eastern Indian Probands

Table 1

Comparative analysis of allelic frequencies in ADHD probands, their parents, and controls.

Gene	Site ID	Allele	Control; (𝑁=180)	Case; (𝑁=170)	𝜒^2; (P)	OR; (95% CI)	Parent; (𝑁=303)	𝜒^2; (P)	OR; (95% CI)
DDC	rs3837091	Del	0.37	0.30	2.4; (0.1)	1.56; (0.87–2.79)	0.40	0.35; (0.6)	0.88; (0.49–1.56)
		AGAG	0.63	0.70			0.60
	rs3735273	G	0.75	0.71	0.92; (0.33)	1.23; (0.66–2.29)	0.70	1.6; (0.21)	1.29; (0.68–2.40)
		A	0.25	0.29			0.30
DRD2	rs1800496	C	1.00	1.00	0.0; (1.0)	—	1.00	0.0; (1.0)	—
		T	0.00	0.00			0
	rs1801028	C	1.00	1.00	0.0; (1.0)	—	1.00	0.0; (1.0)	—
		G	0.00	0.00			0
	rs1799732	C	0.88	0.90	0.93; (0.33)	0.81; (0.33–1.98)	0.89	0.28; (0.60)	0.91; (0.38–2.17)
		Del	0.12	0.10			0.11
DRD4	rs4646984	1 repeat	0.25	0.32	2.83; (0.09)	0.71; (0.38–1.31)	0.33	4.61   (0.03)	0.68; (0.37–1.25)
		2 repeat	0.75	0.68			0.67
	rs4646983	1 repeat	0.08	0.14	4.2   (0.04)	0.53; (0.21–1.34)	0.14	5.18   (0.02)	0.53; (0.22–1.33)
		2 repeat	0.92	0.86			0.86
COMT	rs165599	G	0.34	0.39	1.06; (0.30)	0.81; (0.45–1.43)	0.38	1.67; (0.19)	0.84; (0.47–1.50)
		A	0.66	0.61			0.62
	rs740603	G; A	0.48; 0.52	0.54; 0.46	2.11; (0.14)	0.79; (0.45–1.37)	0.51	0.64; (0.42)	0.89; (0.51–1.54)
							0.49

NB: significant P values are presented in bold.