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BioMed Research International
Volume 2013 (2013), Article ID 918753, 8 pages
http://dx.doi.org/10.1155/2013/918753
Research Article

Detergent-Enzymatic Decellularization of Swine Blood Vessels: Insight on Mechanical Properties for Vascular Tissue Engineering

1Department of Chemistry, Materials and Chemical Engineering “Giulio Natta”, Politecnico di Milano, Milan, Italy
2PhD program in Bioengineering, Politecnico di Milano, Milan, Italy
3Complication of Diabetes Unit, Division of Metabolic and Cardiovascular Sciences, San Raffaele Scientific Institute, Milan, Italy
4General Surgery I, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

Received 8 January 2013; Revised 29 April 2013; Accepted 23 May 2013

Academic Editor: George E. Plopper

Copyright © 2013 Alessandro F. Pellegata et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Peck, D. Gebhart, N. Dusserre, T. N. McAllister, and N. L'Heureux, “The evolution of vascular tissue engineering and current state of the art,” Cells Tissues Organs, vol. 195, no. 1-2, pp. 144–158, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. O. E. Teebken and A. Haverich, “Tissue engineering of small diameter vascular grafts,” European Journal of Vascular and Endovascular Surgery, vol. 23, no. 6, pp. 475–485, 2002. View at Publisher · View at Google Scholar · View at Scopus
  3. R. J. van Det, B. H. R. Vriens, J. van der Palen, and R. H. Geelkerken, “Dacron or ePTFE for femoro-popliteal above-knee bypass grafting: short- and long-term results of a multicentre randomised trial,” European Journal of Vascular and Endovascular Surgery, vol. 37, no. 4, pp. 457–463, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. H. L. Prichard, R. J. Manson, L. DiBernardo, L. E. Niklason, J. H. Lawson, and S. L. M. Dahl, “An early study on the mechanisms that allow tissue-engineered vascular grafts to resist intimal hyperplasia,” Journal of Cardiovascular Translational Research, vol. 4, no. 5, pp. 674–682, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. N. Hibino, E. McGillicuddy, G. Matsumura et al., “Late-term results of tissue-engineered vascular grafts in humans,” Journal of Thoracic and Cardiovascular Surgery, vol. 139, no. 2, pp. 431–436, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. T. N. McAllister, M. Maruszewski, S. A. Garrido et al., “Effectiveness of haemodialysis access with an autologous tissue-engineered vascular graft: a multicentre cohort study,” The Lancet, vol. 373, no. 9673, pp. 1440–1446, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. S. L. M. Dahl, A. P. Kypson, J. H. Lawson et al., “Readily available tissue-engineered vascular grafts,” Science Translational Medicine, vol. 3, no. 68, Article ID 68ra9, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. L. E. Niklason, J. Gao, W. M. Abbott et al., “Functional arteries grown in vitro,” Science, vol. 284, no. 5413, pp. 489–493, 1999. View at Publisher · View at Google Scholar · View at Scopus
  9. Y. Eitan, U. Sarig, N. Dahan, and M. MacHluf, “Acellular cardiac extracellular matrix as a scaffold for tissue engineering: in vitro cell support, remodeling, and biocompatibility,” Tissue Engineering C, vol. 16, no. 4, pp. 671–683, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. T. H. Petersen, E. A. Calle, L. Zhao et al., “Tissue-engineered lungs for in vivo implantation,” Science, vol. 329, no. 5991, pp. 538–541, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Soto-Gutierrez, L. Zhang, C. Medberry et al., “A whole-organ regenerative medicine approach for liver replacement,” Tissue Engineering C, vol. 17, no. 6, pp. 677–686, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Asnaghi, P. Macchiarini, and S. Mantero, “Tissue engineering toward organ replacement: a promising approach in airway transplant,” International Journal of Artificial Organs, vol. 32, no. 11, pp. 763–768, 2009. View at Scopus
  13. S. F. Badylak, D. O. Freytes, and T. W. Gilbert, “Extracellular matrix as a biological scaffold material: structure and function,” Acta Biomaterialia, vol. 5, no. 1, pp. 1–13, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. P. Macchiarini, P. Jungebluth, T. Go et al., “Clinical transplantation of a tissue-engineered airway,” The Lancet, vol. 372, no. 9655, pp. 2023–2030, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. M. A. Asnaghi, P. Jungebluth, M. T. Raimondi et al., “A double-chamber rotating bioreactor for the development of tissue-engineered hollow organs: from concept to clinical trial,” Biomaterials, vol. 30, no. 29, pp. 5260–5269, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. A. F. Pellegata, M. A. Asnaghi, S. Zonta, G. Zerbini, and S. Mantero, “A novel device for the automatic decellularization of biological tissues,” International Journal of Artificial Organs, vol. 35, pp. 191–198, 2012.
  17. A. Remuzzi, S. Mantero, M. Colombo et al., “Vascular smooth muscle cells on hyaluronic acid: culture and mechanical characterization of an engineered vascular construct,” Tissue Engineering, vol. 10, no. 5-6, pp. 699–710, 2004. View at Publisher · View at Google Scholar · View at Scopus
  18. V. Quaglini, T. Villa, F. Migliavacca et al., “An in vitro methodology for evaluating the mechanical properties of aortic vascular prostheses,” Artificial Organs, vol. 26, no. 6, pp. 555–564, 2002. View at Publisher · View at Google Scholar · View at Scopus
  19. C. A. Barnes, J. Brison, R. Michel et al., “The surface molecular functionality of decellularized extracellular matrices,” Biomaterials, vol. 32, no. 1, pp. 137–143, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. T. J. Keane, R. Londono, N. J. Turner, and S. F. Badylak, “Consequences of ineffective decellularization of biologic scaffolds on the host response,” Biomaterials, vol. 33, no. 6, pp. 1771–1781, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. T. W. Gilbert, J. M. Freund, and S. F. Badylak, “Quantification of DNA in biologic scaffold materials,” Journal of Surgical Research, vol. 152, no. 1, pp. 135–139, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. Y. Zou and Y. Zhang, “Mechanical evaluation of decellularized porcine thoracic aorta,” Journal of Surgical Research, vol. 175, pp. 359–368, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. C. Williams, J. Liao, E. M. Joyce et al., “Altered structural and mechanical properties in decellularized rabbit carotid arteries,” Acta Biomaterialia, vol. 5, no. 4, pp. 993–1005, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. B. D. Stemper, N. Yoganandan, M. R. Stineman, T. A. Gennarelli, J. L. Baisden, and F. A. Pintar, “Mechanics of fresh, refrigerated, and frozen arterial tissue,” Journal of Surgical Research, vol. 139, no. 2, pp. 236–242, 2007. View at Publisher · View at Google Scholar · View at Scopus