Table 1: Effects of milk thistle extract (MTE) and silibinin on growth and toxicity in ovariectomized (OVX) mice.

Sham controlOVXOVX-MTEOVX-silibinin

Initial BW (g)22.89 ± 2.5222.92 ± 3.1522.67 ± 2.0422.60 ± 1.69
Final BW (g)23.80 ± 2.31b 26.22 ± 2.64a 24.86 ± 1.95ab 24.18 ± 1.10ab
ADG (mg/d)23.19 ± 3.31c 62.65 ± 9.15a56.80 ± 7.39a37.20 ± 6.50b
ADFI (g/d)3.85 ± 0.06 3.86 ± 0.064.03 ± 0.063.75 ± 0.06
FER 0.59 ± 0.08c 1.62 ± 0.24a 1.39 ± 0.18a 0.99 ± 0.16b
Liver weight (g) 1.17 ± 0.08 1.14 ± 0.06 1.14 ± 0.03 1.13 ± 0.05
LW/BW (%) 4.86 ± 0.27a 4.38 ± 0.12b 4.54 ± 0.19ab 4.67 ± 0.25a
Serum GOP (IU/L)50.35 ± 1.94 50.25 ± 1.6250.16 ± 1.3248.71 ± 1.69
Serum GPT (IU/L)22.84 ± 1.31 21.96 ± 1.3721.77 ± 1.7721.71 ± 1.32

C57BL/6 female mice (11 weeks of age, 20–25 g) were surgically ovariectomized and orally supplemented with 10 mg/kg MTE and silibinin daily for 8 weeks. BW: body weight; ADG: average daily gain; ADFI: average daily food intake; FER: food efficiency ratio; OVX: ovariectomy; LW: liver weight. Values are means ± SEM of 9 mice. Respective values in the same row not sharing the same superscript differ, .