Table 2: Osteogenic activity of milk thistle extract (MTE) and silibinin in ovariectomized (OVX) mice.

Sham controlOVXOVX-MTEOVX-silibinin

BMD74.4 ± 2.0a61.0 ± 0.8c72.5 ± 1.9a67.4 ± 0.4b
BMC17.6 ± 0.4a15.1 ± 0.2c17.2 ± 0.7a16.4 ± 0.2b
Bone area0.237 ± 0.0030.250 ± 0.0040.238 ± 0.0060.244 ± 0.004

C57BL/6 female mice (11 weeks of age, 20–25 g) were ovariectomized and orally supplemented with 10 mg/kg MTE and silibinin daily for 8 weeks. Areal bone mineral density (BMD, mg/cm2), bone mineral content (BMC, mg), and bone area (cm2) were measured in femur bones by using a PIXImus mouse densitometer. Values are means ± SEM of 9 mice. Respective values in the same row not sharing the same superscript differ, .