Protective Effect of Spin-Labeled 1-Ethyl-1-nitrosourea against Oxidative Stress in Liver Induced by Antitumor Drugs and Radiation

Table 1

The influence of i.p. administration of SLENU on sGPT and sGOT liver transaminases in BLM, DOX, and R-treated mice.

Compound	sGOT (U/L)	sGPT (U/L)
Controls (health)	60.20±2.60	31.00±0.44
Controls (tumor)	63.27±1.43	36.15±1.74
BLM (60 mg/kg)	78.90±4.10	44.23±0.81
DOX (60 mg/kg)	177.87±2.30^∗	142.33±1.21^∗
R	181.80±3.12^∗	134.56±0.90^∗
SLENU (100 mg/kg)	62.88±2.04	39.27±1.98
BLM (60 mg/kg) + SLENU (100 mg/kg)	66.50±1.40	41.20±0.62
DOX (60 mg/kg) + SLENU (100 mg/kg)	80.30±1.27^#	49.89±1.02^#
R (60 mg/kg) + SLENU (100 mg/kg)	77.45±1.13^#	37.10±0.77^#

Data are expressed as mean ± SE; *𝑃<0.00001 versus tumor controls; ^#𝑃<0.0001 versus corresponding DOX or R-treated mice.