Lactobacilli Reduce Chemokine IL-8 Production in Response to TNF-α and Salmonella Challenge of Caco-2 Cells
Figure 4
Effect of lactobacilli on IL-8 production by Caco-2 cells in a proinflammatory context. Caco-2 cells were pretreated with TNF-α to mimic an inflammatory background and then treated with live lactobacilli (1 × 107, 1 × 108, and 1 × 109 CFU/mL) or related preparations. (a) L. salivarius; (b) L. plantarum; (c) LGG. Caco-2 cells treated only with TNF-α were used as positive controls. Values are presented as means ± SD . , compared with TNF-α-stimulated cells without lactobacilli treatment. CM: cell-free conditioned medium of lactobacilli; MRS: de Man-Rogosa-Sharpe broth (pH 4.0).
