Synthesis of a Novel Thiazolidinedione and Evaluation of Its Modulatory Effect on IFN-γ, IL-6, IL-17A, and IL-22 Production in PBMCs from Rheumatoid Arthritis Patients

Figure 3

Evaluation of cytokines release inhibition by TM17 compound in PBMC culture from RA patients. (a) TM17 in 100 μM as well as positive control (methylprednisolone) was able to decrease significantly INF-γ levels. The same pattern was observed for IL17A (b). (c) IL22 was significantly inhibited in all tested concentrations. (d) IL-6 was not significantly inhibited either by TM17 or by methylprednisolone. ^∗𝑃<0.05,^∗∗𝑃<0.01.

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