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BioMed Research International
Volume 2013 (2013), Article ID 926942, 13 pages
2-Heptyl-Formononetin Increases Cholesterol and Induces Hepatic Steatosis in Mice
1Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, 1870 Frederiksberg C, Denmark
2Department of Chemistry, Faculty of Science, University of Copenhagen, 1870 Frederiksberg C, Denmark
3Department of Food Science, Faculty of Science, University of Copenhagen, 1870 Frederiksberg C, Denmark
4Department of Biology, Faculty of Science, University of Copenhagen, 2200 Copenhagen N, Denmark
5Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen Ø, Denmark
Received 2 January 2013; Revised 15 March 2013; Accepted 26 March 2013
Academic Editor: Kazim Husain
Copyright © 2013 Charlotte Andersen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- C. R. Cederroth and S. Nef, “Soy, phytoestrogens and metabolism: a review,” Molecular and Cellular Endocrinology, vol. 304, no. 1-2, pp. 30–42, 2009.
- M. S. Kurzer and X. Xu, “Dietary phytoestrogens,” Annual Review of Nutrition, vol. 17, pp. 353–381, 1997.
- A. Ørgaard and L. Jensen, “The effects of soy isoflavones on obesity,” Experimental Biology and Medicine, vol. 233, no. 9, pp. 1066–1080, 2008.
- T. Usui, “Pharmaceutical prospects of phytoestrogens,” Endocrine Journal, vol. 53, no. 1, pp. 7–20, 2006.
- R. P. Patel and S. Barnes, “Isoflavones and PPAR signaling: a critical target in cardiovascular, metastatic, and metabolic disease,” PPAR Research, Article ID 153252, 2010.
- M. Yalniz, I. H. Bahcecioglu, N. Kuzu et al., “Preventive role of genistein in an experimental non-alcoholic steatohepatitis model,” Journal of Gastroenterology and Hepatology, vol. 22, no. 11, pp. 2009–2014, 2007.
- K. Taku, K. Umegaki, Y. Sato, Y. Taki, K. Endoh, and S. Watanabe, “Soy isoflavones lower serum total and LDL cholesterol in humans: a meta-analysis of 11 randomized controlled trials,” The American Journal of Clinical Nutrition, vol. 85, no. 4, pp. 1148–1156, 2007.
- X. G. Zhuo, M. K. Melby, and S. Watanabe, “Soy isoflavone intake lowers serum LDL cholesterol: a meta-analysis of 8 randomized controlled trials in humans,” The Journal of Nutrition, vol. 134, no. 9, pp. 2395–2400, 2004.
- M. H. Kim, J. S. Park, J. W. Jung, K. W. Byun, K. S. Kang, and Y. S. Lee, “Daidzein supplementation prevents non-alcoholic fatty liver disease through alternation of hepatic gene expression profiles and adipocyte metabolism,” International Journal of Obesity, vol. 35, pp. 1019–1030, 2011.
- M. H. Kim, K. S. Kang, and Y. S. Lee, “The inhibitory effect of genistein on hepatic steatosis is linked to visceral adipocyte metabolism in mice with diet-induced non-alcoholic fatty liver disease,” British Journal of Nutrition, vol. 104, no. 9, pp. 1333–1342, 2010.
- M. Penza, C. Montani, A. Romani et al., “Genistein affects adipose tissue deposition in a dose-dependent and gender-specific manner,” Endocrinology, vol. 147, no. 12, pp. 5740–5751, 2006.
- J. Y. Yang, S. J. Lee, H. W. Park, and Y. S. Cha, “Effect of genistein with carnitine administration on lipid parameters and obesity in C57B1/6J mice fed a high-fat diet,” Journal of Medicinal Food, vol. 9, no. 4, pp. 459–467, 2006.
- S. S. Mohamed, P. Nallasamy, P. Muniyandi, V. Periyasami, and A. Carani Venkatraman, “Genistein improves liver function and attenuates non-alcoholic fatty liver disease in a rat model of insulin resistance,” Journal of diabetes, vol. 1, no. 4, pp. 278–287, 2009.
- A. Crespillo, M. Alonso, M. Vida et al., “Reduction of body weight, liver steatosis and expression of stearoyl-CoA desaturase 1 by the isoflavone daidzein in diet-induced obesity,” British Journal of Pharmacology, vol. 164, pp. 1899–1915, 2011.
- Y. M. Lee, J. S. Choi, M. H. Kim, M. H. Jung, Y. S. Lee, and J. Song, “Effects of dietary genistein on hepatic lipid metabolism and mitochondrial function in mice fed high-fat diets,” Nutrition, vol. 22, no. 9, pp. 956–964, 2006.
- N. Yumiko, K. Akiko, T. Yukari, I. Susumu, and T. Yasuhide, “Content and composition of isoflavonoids in mature or immature beans and bean sprouts consumed in Japan,” Journal of Health Science, vol. 47, pp. 394–406, 2001.
- G. Pakalapati, L. Li, N. Gretz, E. Koch, and M. Wink, “Influence of red clover (Trifolium pratense) isoflavones on gene and protein expression profiles in liver of ovariectomized rats,” Phytomedicine, vol. 16, no. 9, pp. 845–855, 2009.
- P. Shen, M. H. Liu, T. Y. Ng, Y. H. Chan, and E. L. Yong, “Differential effects of isoflavones, from Astragalus Membranaceus and Pueraria Thomsonii, on the activation of PPARα, PPARγ, and adipocyte differentiation in vitro,” The Journal of Nutrition, vol. 136, no. 4, pp. 899–905, 2006.
- S. Zhang, X. Tang, J. Tian et al., “Cardioprotective effect of sulphonated formononetin on acute myocardial infarction in rats,” Basic and Clinical Pharmacology and Toxicology, vol. 108, no. 6, pp. 390–395, 2011.
- D. S. Pedersen and C. Rosenbohm, “Dry column vacuum chromatography,” Synthesis, no. 16, pp. 2431–2434, 2001.
- S. A. Schreyer, D. L. Wilson, and R. C. Leboeuf, “C57BL/6 mice fed high fat diets as models for diabetes-accelerated atherosclerosis,” Atherosclerosis, vol. 136, no. 1, pp. 17–24, 1998.
- J. S. Kang, W. K. Lee, C. W. Lee et al., “Improvement of high-fat diet-induced obesity by a mixture of red grape extract, soy isoflavone and l-carnitine: implications in cardiovascular and non-alcoholic fatty liver diseases,” Food and Chemical Toxicology, vol. 49, no. 9, pp. 2453–2458, 2011.
- P. A. Flecknell, Laboratory Animal Anaesthesia, Academic Press, London, UK, 1996.
- S. D. Christensen, L. F. Mikkelsen, J. J. Fels, T. B. Bodvarsdóttir, and A. K. Hansen, “Quality of plasma sampled by different methods for multiple blood sampling in mice,” Laboratory Animals, vol. 43, no. 1, pp. 65–71, 2009.
- K. Dahl, K. Buschard, D. X. Gram, A. J. F. D'Apice, and A. K. Hansen, “Glucose intolerance in a xenotransplantation model: studies in alpha-gal knockout mice,” APMIS, vol. 114, no. 11, pp. 805–811, 2006.
- L. Ovreås, L. Forney, F. L. Daae, and V. Torsvik, “Distribution of bacterioplankton in meromictic lake saelenvannet, as determined by denaturing gradient gel electrophoresis of PCR-amplified gene fragments coding for 16S rRNA,” Applied and Environmental Microbiology, vol. 63, no. 9, pp. 3367–3373, 1997.
- H. J. Flint, “Obesity and the gut microbiota,” Journal of Clinical Gastroenterology, vol. 45, pp. S128–S132, 2011.
- S. Ae Park, M. S. Choi, S. Y. Cho et al., “Genistein and daidzein modulate hepatic glucose and lipid regulating enzyme activities in C57BL/KsJ-db/db mice,” Life Sciences, vol. 79, no. 12, pp. 1207–1213, 2006.
- M. S. Choi, U. J. Jung, J. Yeo, M. J. Kim, and M. K. Lee, “Genistein and daidzein prevent diabetes onset by elevating insulin level and altering hepatic gluconeogenic and lipogenic enzyme activities in non-obese diabetic (NOD) mice,” Diabetes/Metabolism Research and Reviews, vol. 24, no. 1, pp. 74–81, 2008.
- Y. J. Moon, X. Wang, and M. E. Morris, “Dietary flavonoids: effects on xenobiotic and carcinogen metabolism,” Toxicology in Vitro, vol. 20, no. 2, pp. 187–210, 2006.
- E. Fabbrini, S. Sullivan, and S. Klein, “Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications,” Hepatology, vol. 51, no. 2, pp. 679–689, 2010.
- J. W. Wu, S. P. Wang, F. Alvarez et al., “Deficiency of liver adipose triglyceride lipase in mice causes progressive hepatic steatosis,” Hepatology, vol. 54, no. 1, pp. 122–132, 2011.
- E. S. Shin, H. H. Lee, S. Y. Cho, H. W. Park, S. J. Lee, and T. R. Lee, “Genistein downregulates SREBP-1 regulated gene expression by inhibiting site-1 protease expression in HepG2 cells,” The Journal of Nutrition, vol. 137, no. 5, pp. 1127–1131, 2007.
- S. Kim, I. Sohn, Y. S. Lee, and Y. S. Lee, “Hepatic gene expression profiles are altered by genistein supplementation in mice with diet-induced obesity,” The Journal of Nutrition, vol. 135, no. 1, pp. 33–41, 2005.
- M. J. Ronis, Y. Chen, J. Badeaux, and T. M. Badger, “Dietary soy protein isolate attenuates metabolic syndrome in rats via effects on PPAR, LXR, and SREBP signaling,” The Journal of Nutrition, vol. 139, no. 8, pp. 1431–1438, 2009.
- K. Minehira, S. G. Young, C. J. Villanueva et al., “Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice,” Journal of Lipid Research, vol. 49, no. 9, pp. 2038–2044, 2008.
- F. Rodríguez-Sanabria, A. Rull, G. Aragonès et al., “Differential response of two models of genetically modified mice fed with high fat and cholesterol diets: relationship to the study of non-alcoholic steatohepatitis,” Molecular and Cellular Biochemistry, vol. 343, no. 1-2, pp. 59–66, 2010.
- N. M. Borradaile, L. E. De Dreu, L. J. Wilcox, J. Y. Edwards, and M. W. Huff, “Soya phytoestrogens, genistein and daidzein, decrease apolipoprotein B secretion from HepG2 cells through multiple mechanisms,” Biochemical Journal, vol. 366, no. 2, pp. 531–539, 2002.
- H. J. Park, M. A. Della-Fera, D. B. Hausman, S. Rayalam, S. Ambati, and C. A. Baile, “Genistein inhibits differentiation of primary human adipocytes,” Journal of Nutritional Biochemistry, vol. 20, no. 2, pp. 140–148, 2009.
- K. Szkudelska, L. Nogowski, and T. Szkudelski, “Genistein affects lipogenesis and lipolysis in isolated rat adipocytes,” Journal of Steroid Biochemistry and Molecular Biology, vol. 75, no. 4-5, pp. 265–271, 2000.
- A. W. Harmon and J. B. Harp, “Differential effects of flavonoids on 3T3-L1 adipogenesis and lipolysis,” American Journal of Physiology, vol. 280, no. 4, pp. C807–C813, 2001.
- K. Kandulska, L. Nogowski, and T. Szkudelski, “Effect of some phytoestrogens on metabolism of rat adipocytes,” Reproduction Nutrition Development, vol. 39, no. 4, pp. 497–501, 1999.
- G. Ji, Q. Yang, J. Hao et al., “Anti-inflammatory effect of genistein on non-alcoholic steatohepatitis rats induced by high fat diet and its potential mechanisms,” International Immunopharmacology, vol. 11, no. 6, pp. 762–768, 2011.
- A. P. Rolo, J. S. Teodoro, and C. M. Palmeira, “Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis,” Free Radical Biology and Medicine, vol. 52, no. 1, pp. 59–69, 2012.
- C. E. Rüfer and S. E. Kulling, “Antioxidant activity of isoflavones and their major metabolites using different in vitro assays,” Journal of Agricultural and Food Chemistry, vol. 54, no. 8, pp. 2926–2931, 2006.
- L. Qiu, H. Ye, L. Chen, Y. Hong, F. Zhong, and T. Zhang, “Red clover extract ameliorates dyslipidemia in streptozotocin-induced diabetic C57BL/6 mice by activating hepatic PPARalpha,” Phytotherapy Research, vol. 26, no. 6, pp. 860–864, 2011.
- A. A. Pendse, J. M. Arbones-Mainar, L. A. Johnson, M. K. Altenburg, and N. Maeda, “Apolipoprotein E knock-out and knock-in mice: atherosclerosis, metabolic syndrome, and beyond,” Journal of lipid research, vol. 50, pp. S178–182, 2009.