Table 2: Plasma lipid profiles of C57BL/6 mice before cholesterol feeding, after five weeks of initial cholesterol feeding and after three additional weeks where the mice were fed the cholesterol-enriched diet supplemented with either formononetin or 2-heptyl-formonetin (C7F) (Experiment  1). Data show mean ± SEM. Different letters (a, b, c, d) denote significant difference (P ≤ 0.05) between the groups.

Total cholesterol
(mmol/L)
HDL
(mmol/L)
LDL
(mmol/L)
Triglycerides
(mmol/L)

Before test period

After acclimatisation ( )3.12 ± 0.20a1.39 ± 0.10a0.32 ± 0.051.95 ± 0.55a
After initial cholesterol feeding ( )3.22 ± 0.26ab1.40 ± 0.11ab0.35 ± 0.071.13 ± 0.30ab

After test period

Cholesterol ( )3.32 ± 0.25bc1.46 ± 0.15b0.29 ± 0.060.95 ± 0.27c
Cholesterol + formononetin ( )3.43 ± 0.27c1.44 ± 0.16ab0.34 ± 0.141.16 ± 0.29b
Cholesterol + C7F ( )3.83 ± 0.54d1.78 ± 0.18c0.28 ± 0.101.03 ± 0.39bc