2-Heptyl-Formononetin Increases Cholesterol and Induces Hepatic Steatosis in Mice

Table 2

Plasma lipid profiles of C57BL/6 mice before cholesterol feeding, after five weeks of initial cholesterol feeding and after three additional weeks where the mice were fed the cholesterol-enriched diet supplemented with either formononetin or 2-heptyl-formonetin (C7F) (Experiment  1). Data show mean ± SEM. Different letters (a, b, c, d) denote significant difference (P ≤ 0.05) between the groups.

	Total cholesterol; (mmol/L)	HDL; (mmol/L)	LDL; (mmol/L)	Triglycerides; (mmol/L)
Before test period
After acclimatisation (𝑛=30)	3.12 ± 0.20^a	1.39 ± 0.10^a	0.32 ± 0.05	1.95 ± 0.55^a
After initial cholesterol feeding (𝑛=23)	3.22 ± 0.26^ab	1.40 ± 0.11^ab	0.35 ± 0.07	1.13 ± 0.30^ab
After test period
Cholesterol (𝑛=25)	3.32 ± 0.25^bc	1.46 ± 0.15^b	0.29 ± 0.06	0.95 ± 0.27^c
Cholesterol + formononetin (𝑛=23)	3.43 ± 0.27^c	1.44 ± 0.16^ab	0.34 ± 0.14	1.16 ± 0.29^b
Cholesterol + C7F (𝑛=25)	3.83 ± 0.54^d	1.78 ± 0.18^c	0.28 ± 0.10	1.03 ± 0.39^bc