A Simple Assay to Screen Antimicrobial Compounds Potentiating the Activity of Current Antibiotics

Table 1

Juglans regia extract helped enhance the efficacy of synthetic antibiotics and overcame the resistant phenotype. Data are presented as the mean ± standard error of three independent experiments.

Antibiotic	Zone of inhibition, mm (antibiotic alone)	Zone of inhibition, mm (antibiotic + Juglans regia extract)	𝑃 value*
Aztreonam (MDR Salmonella typhi)	20±3.4	29±6.2	<0.01
Cefuroxime (MDR Salmonella typhi)	12.5±2.2	18±2.5	<0.01
Ampicillin (MDR Salmonella typhi)	13±2.5	19±1.8	<0.001
Aztreonam (MDR enteropathogenic E. coli)	14.5±3.5	21±5.3	<0.01
Cefixime (MDR enteropathogenic E. coli)	16±5.1	22±4.7	>0.05
Ampicillin (MDR enteropathogenic E. coli)	13±0.9	18±3.1	>0.01

^∗𝑃 values were calculated using one-tailed paired 𝑡-test.