A Case-Control Study between Gene Polymorphisms of Polyunsaturated Fatty Acid Metabolic Rate-Limiting Enzymes and Acute Coronary Syndrome in Chinese Han Population
Table 6
Stratified analysis between the rs174617 and rs3756963 T>C polymorphisms and risk of ACS by hypertension, DM, and smoking.
Case ()
Control ()
Adjusted OR (95% CI)a
TT (%)
CC + CT (%)
TT (%)
CC + CT (%)
TT
CC + CT
Rs174617 T>C genotypes
Hypertension
No
51 (58.0)
37 (42.0)
109 (75.7)
35 (24.3)
1.00
2.326 (1.327–4.120)
Yes
90 (58.4)
64 (41.6)
40 (41.7)
56 (58.3)
1.00
0.492 (0.262–0.812)
DM
No
88 (54.0)
75 (46.0)
135 (64.3)
75 (35.7)
1.00
1.242 (1.006–2.012)
Yes
60 (69.8)
26 (30.2)
14 (46.7)
16 (53.3)
1.00
0.326 (0.126–0.801)
Smoking
No
58 (82.8)
29 (17.2)
113 (73.4)
41 (26.6)
1.00
0.524 (0.326–0.884)
Yes
90 (46.9)
72 (53.1)
36 (41.9)
50 (58.1)
1.00
0.628 (0.412–1.021)
No 3 risk
50 (71.4)
20 (28.6)
60 (65.2)
32 (34.8)
1.00
0.782 (0.382–1.410)
Rs3756963 T>C genotypes
Hypertension
No
67 (70.5)
28 (29.5)
115 (79.9)
29 (20.1)
1.00
1.542 (0.743–2.732)
Yes
74 (48.1)
80 (51.9)
30 (31.2)
66 (68.8)
1.00
0.524 (0.301–0.980)
DM
No
89 (16.0)
74 (84.0)
125 (59.5)
85 (40.5)
1.00
1.364 (0.896–1.868)
Yes
52 (60.5)
34 (39.5)
20 (66.7)
10 (33.3)
1.00
0.692 (0.284–1.790)
Smoking
No
59 (11.5)
28 (88.5)
105 (31.8)
49 (68.2)
1.00
0.423 (0.298–0.792)
Yes
82 (53.1)
80 (46.9)
40 (81.4)
46 (18.6)
1.00
0.920 (0.583–1.492)
No 3 risk
60 (85.7)
10 (14.3)
80 (74.1)
28 (25.9)
1.00
0.524 (0.301–1.162)
aAjusted for age, sex, and the presence of diabetes, hypertension, and smoking status except the stratified factor at each stratum.
