High-Dose, but Not Low-Dose, Aspirin Impairs Anticontractile Effect of Ticagrelor following ADP Stimulation in Rat Tail Artery Smooth Muscle Cells
Figure 3
pD2 values in arteries with and without vascular endothelium obtained for phenylephrine in the absence and presence of low-dose aspirin, high-dose aspirin, and ticagrelor coadministered with 2-MeS-ADP. Measurements for phenylephrine alone represent controls. ASA (H): high-dose aspirin; ASA (L): low-dose aspirin; Ea/Em: % of maximal response; EC50: molar concentration producing 50% of the maximal response; pD2: negative logarithm of EC50; TIC: ticagrelor; 2-MeS-ADP: stable analogue of adenosine diphosphate.
