Review Article

A Comprehensive Focus on Global Spectrum of BRCA1 and BRCA2 Mutations in Breast Cancer

Table 7

BRCA1 and BRCA2 gene mutations in Southern and Western Asia.

CountryBRCA1 mutationsBRCA2 mutations Founder mutations

SingaporeExon 13 dup, 13–15 del [205], c.2845insA [206]Exons 4–11 dup [205]c.2845insA [206]
Malaysiac.2845insA [206], 4427T>C, 2846insA, 2201C>T and 4956A>G (79%), 3668A>G [207], 2731C>T, 3232A.G, 3667A.G [24], exon 3 dup [108]
4859delA, 4265delCT [208], 1342C.A [24]
490 delCT
c.2845insA [206]
Pakistan4627C>A (22%) [107], 4184del4 (15%), 185delAG and 2080insA and IVS14−1G>A (11%), 2041insA and 4284delAG (8%), 3889delAG and 2388delG (7%) [106]3337C>T (50%), 5057delTG (50%) [106]4627C>A, 185delAG, 185insA [107]
Iran
g.-1075C>G, g.-235A>G
g.-134T>C, g.442−34C>T, g.548–58delT
c.2077G>A, c.2082C>T
c.2311T>C, c.2612C>T
c.3113A>G, c.3119G>A
c.3548A>G, c.4308T>C
c.4837A>G, g.4987−68A>G, g.4987−92A>G
g.5075−53C>T, g.5152+66G>A
g.381_389del9ins29
g. 421G>T, g. 1286C>T [34] IVS16−92A>G, IVS16−68A>G, 4837A>G, IVS18+65G>A [133], Tyr978X,
g.-1235G>A, g.-26G>A
g.681+56C>T, c.865A>C
c.1114A>C, c.1365A>G
c.2229T>C, c.2971A>G
c.3396A>G, c.3516G>A
c.3807T>C
c.4415_4418delAGAA
c.5529A>C, c.6033_6034insGT
c.7242A>G, g.7435+53C>T
g.7806−14T>C
g.8755−66T>C [34]
c.4415-4418delAGAA and c.6033insGT [134]
c.5576_5579delTTAA
c.9485−1G>A [209]

LebanonIVS17−53C>T and g.381-389del9ins29 [134], 5382insC [138]
G2031T [135]
India185delAG [122, 123], 2983C>A, 3450delCAAG [123, 124], c.3548A>G, c.-26G>A, c.317-54C>G [125],
5341T>G, 5364C>G, 5379 G>T [210]
1014DelGT and 3889DelAG [126]
5382insC [127]
185delAG [122]
Sri Lankac.3086delT, c.5404delG, c.856T>G, IVS17−2A>T [23]
Philippines5454delC [208]4265delCT and 4859delA [208]5454delC, 4265delCT, 4859delA [208]
Indonesia (in South eastern Asia)6775G>T,
p.Glu2183X,
c.2699_2704delTAAATG
[211]
c.2699_2704delTAAATG [211]
Vietnam185insA [212]4706delAAAG [212]
Thailand
3300delA [202]

Israel (in Western Asia)185delAG, Tyr978X, A1708E, 981delAT, C61G [141]R2336P, IVS2+1G>A, 8765delAG [141]