A Comprehensive Focus on Global Spectrum of BRCA1 and BRCA2 Mutations in Breast Cancer

Table 8

BRCA1 and BRCA2 gene mutations in Africa.

Country	BRCA1 mutations	BRCA2 mutations	Founder mutations
Nigeria	Exon 21 del (c.5277+480_5332+672del), intron 20 (AluSg), intron 21 (AluY) [14]	—	—
Egypt	185 del AG, 5454 del C, 4446C>T, 738C>A [213]	999 del 5 [213]	999 del 5, 185 del AG, 5454 del C [213]
Tunisia	330 dupA (novel), 4160 delAG, the 2789 delG, 5385 insC [214], c.4041delAG, c.2551delG and c.5266dupC, c.798_799delTT [215]	1537 del4 and 5909 insA [214], c.211dupA [215]	—
Algeria	c.46_74del29, c.798_799delTT [143]	—	—
Morocco	c.1016dupA, c.798_799delTT, c.5095C>T, c.4942A>T, c.2805delA/2924delA [146]	c.3381delT/3609delT, c.7110delA/7338delA, c.7235insG/7463insG [216]	c.798_799delTT [146]
Western cape of South Africa	c.1504_1508del; [145]	c.2826_2829del, c.6447_6448dup, c.5771_5774del, 5999del4 [145]	5999del4 [145]