The Roles of Hyaluronan/RHAMM/CD44 and Their Respective Interactions along the Insidious Pathways of Fibrosarcoma Progression

Figure 1

Hyaluronan/RHAMM/CD44-dependent signaling affects fibrosarcoma cell functions. (a) Interactions of cell membrane RHAMM with growth factor receptors (GFR) in a c-src/ERK1,2 dependent manner modulate transcription of motogenic effectors, and RHAMM/GFR interactions through c-src signaling induce FAK phosphorylation and focal adhesion complex formation. Interactions of cell membrane RHAMM with CD44 and GFRs in a c-src/ras/ERK1,2 dependent manner modulate transcription of motogenic effectors to regulate fibrosarcoma motility. (d) Cytoplasmatic RHAMM through RHAMM/MEK/ERK1,2 complex formation regulates mitotic spindle formation affecting cell growth. (e) Activated RHAMM positioned to nucleus forms complexes with transcription facors, for example, TPX2 to regulate expression of cell cycle mediators.