BioMed Research International

Clinical Study

Kidney Dosimetry in 177Lu and 90Y Peptide Receptor Radionuclide Therapy: Influence of Image Timing, Time-Activity Integration Method, and Risk Factors

Table 1

Statistical results ( and SSE) and computed by means of different fitting functions, with distinction between DOTATOC and DOTATATE peptides, with and without accumulation behaviour. Concerning , a single value for each peptide was computed, irrespective of the kinetic behaviour. A negative (obtained in 6 MNfix fits) means that a constant function equal to the mean value of the data would fit better; that is, the fit is of very poor quality.
Biological constants
Cases with accumulationClearance only cases
Mean medianSEE medianMean medianSEE median
(range) (range)(range)(range) (range)(range)
DOTATATE       
8.60.71 1.6–0.99)0.89 (0.07–5.30)8.60.81 (0.40–0.99)0.58 (0.004–4.04)
(2–13)0.82 (0.08–0.98)0.59 (0.007–1.83) (5–21)0.94 (0.57–0.99)0.25 (0.002–1.07)
(42–427)0.99 (0.75–1)0.017 (0.001–0.147) (9–311)0.98 (0.75–0.99)0.092 (0–1.057)
(6–21)   (0–162)  
DOTATOC       
11.04−0.71 1.47–0.60)2.32 (1.05–11.24)11.040.82 (0.36–0.98)0.49 (0.05–9.09)
(1–7)0.57 (0.01–0.93)0.34 (0.13–4.71) (7–24)0.97 (0.66–1.00)0.17 (0.002–5.26)
(28–308)1 (0.89–1)0.01 (0–0.02) (9–443)0.99 (0.80–1)0.025 (0–0.364)
(6–22)   (0–22)