Urinary IgG and α2-Macroglobulin Are Powerful Predictors of Outcome and Responsiveness to Steroids and Cyclophosphamide in Idiopathic Focal Segmental Glomerulosclerosis with Nephrotic Syndrome

Table 1

Baseline clinical characteristics of 38 patients with FSGS and NS.

No. of patients	38	Range
Age (yrs)	39 ± 18	14–80
Sex (M/F)	21/17
eGFR (mL/min/1.73 m^2)	80 ± 31	30–123
eGFR <60 mL/min/1.73 m^2	29%
BP ≥140/90 mmHg	55%
Serum albumin	2.26 ± 0.72	0.98–3.76
24 hP	8.5 ± 5.7	3.5–32.7
UP/C	6111 ± 4246	253–20283
α2m/C	3.4 ± 5.2	0–18.7
FE IgG	0.091 ± 0.112	0.003–0.534
FE α1m	0.305 ± 0.260	0.007–0.945
No. of glomeruli in RB (no. 35)	14 ± 6	6–32
GGS%	7 ± 10	0–37
TID score	2.0 ± 1.5	0–6
SS%	21 ± 15	5–70
Overall follow-up (mths)	96 ± 67	12–236
Follow-up of pts. without ESRD	115 ± 63	24–236

eGFR: estimated GFR; BP: blood pressure; 24 hP: 24 hour proteinuria; UP/C: urinary protein/creatinine ratio; α2m/C: urinary α2m/creatinine ratio; FE IgG: fractional excretion of IgG; FE α1m: fractional excretion of α1-microglobulin; RB: renal biopsy; GGS: global glomerular sclerosis; TID score: tubulointerstitial damage score; SS: segmental sclerosis.