Urinary IgG and α2-Macroglobulin Are Powerful Predictors of Outcome and Responsiveness to Steroids and Cyclophosphamide in Idiopathic Focal Segmental Glomerulosclerosis with Nephrotic Syndrome
Table 4
ESRD and remission rate in 38 patients with FSGS and NS according to functional, proteinuric, and histological markers.
ESRD no. 9 (24%)
Remission no. 23 (61%)
FE IgG 0 versus 1 (26 versus 12)
0% versus 75% (<0.0001)
77% versus 25% (0.016)
24 hP 0 versus 1 (20 versus 18)
0% versus 50% (0.001)
75% versus 44% (0.10)
UP/C 0 versus 1 (22 versus 16)
0% versus 56% (<0.0001)
73% versus 44% (0.11)
eGFR 0 versus 1 (20 versus 18)
30% versus 17% (0.23)
65% versus 56% (0.10)
FE α1m 0 versus 1 (28 versus 10)
7% versus 70% (<0.0001)
71% versus 30% (0.06)
α2m/C 0 versus 1 (26 versus 12)
4% versus 67% (<0.0001)
81% versus 17% (0.007)
FE IgG 0 + α2m/C 0 (23) versus FE IgG 1 + α2m/C 1 (9)
0% versus 89% (<0.0001)
83% versus 11% (0.008)
SS 0 versus 1 (17 versus 18)
6% versus 39% (0.018)
82% versus 44% (0.11)
GGS 0 versus 1 (21 versus 14)
24% versus 21% (0.80)
67% versus 57% (0.71)
TID score 0 versus 1 (22 versus 13)
27% versus 15% (0.39)
64% versus 62% (0.26)
FE IgG 0 versus 1: < versus ≥ 0.112; 24 hP 0 versus 1: < versus ≥ 6.8 g/24 hours; UP/C 0 versus 1: < versus ≥ 5980 mg/g uCr; eGFR 0 versus 1: < versus ≥ 68 mL/min/1.73 m2; FE α1m 0 versus 1: < versus ≥ 0.362; α2m/C 0 versus 1: < versus ≥ 4.79 mg/g uCr; SS 0 versus 1: < versus ≥ 16%; GGS 0 versus 1: < versus ≥ 7%; TID score 0 versus 1: < versus ≥ 3.
