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BioMed Research International
Volume 2013 (2013), Article ID 942916, 15 pages
http://dx.doi.org/10.1155/2013/942916
Review Article

Mechanisms of Nanoparticle-Induced Oxidative Stress and Toxicity

1Department of Pharmaceutical Sciences and Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506, USA
2Physiology and Pathology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA

Received 9 May 2013; Accepted 16 July 2013

Academic Editor: Nikhat J. Siddiqi

Copyright © 2013 Amruta Manke et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. D. Maynard, P. A. Baron, M. Foley, A. A. Shvedova, E. R. Kisin, and V. Castranova, “Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material,” Journal of Toxicology and Environmental Health A, vol. 67, no. 1, pp. 87–107, 2004. View at Scopus
  2. K. Donaldson, F. A. Murphy, R. Duffin, and C. A. Poland, “Asbestos, carbon nanotubes and the pleural mesothelium: a review of the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma,” Particle and Fibre Toxicology, vol. 7, article 5, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. A. Nel, T. Xia, L. Mädler, and N. Li, “Toxic potential of materials at the nanolevel,” Science, vol. 311, no. 5761, pp. 622–627, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. Y. Huang, C. Wu, and R. Aronstam, “Toxicity of transition metal oxide nanoparticles: recent insights from in vitro Studies,” Materials, vol. 3, no. 10, pp. 4842–4859, 2010.
  5. G. M. Stella, “Carbon nanotubes and pleural damage: perspectives of nanosafety in the light of asbestos experience,” Biointerphases, vol. 6, no. 2, pp. P1–P17, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. A. A. Shvedova, A. Pietroiusti, B. Fadeel, and V. E. Kagan, “Mechanisms of carbon nanotube-induced toxicity: focus on oxidative stress,” Toxicology and Applied Pharmacology, vol. 261, no. 2, pp. 121–133, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Pojlak-Blazi, M. Jaganjac, and N. Zarkovic, “Cell oxidative stress: risk of metal nanoparticles,” in Handbook of Nanophysics: Nanomedicine and Nanorobotics, pp. 1–17, CRC Press, New York, NY, USA, 2010.
  8. Y. Ju-Nam and J. R. Lead, “Manufactured nanoparticles: an overview of their chemistry, interactions and potential environmental implications,” Science of the Total Environment, vol. 400, no. 1–3, pp. 396–414, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. N. Li, T. Xia, and A. E. Nel, “The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles,” Free Radical Biology and Medicine, vol. 44, no. 9, pp. 1689–1699, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. V. Stone, H. Johnston, and M. J. D. Clift, “Air pollution, ultrafine and nanoparticle toxicology: cellular and molecular interactions,” IEEE Transactions on Nanobioscience, vol. 6, no. 4, pp. 331–340, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. H. J. Johnston, G. Hutchison, F. M. Christensen, S. Peters, S. Hankin, and V. Stone, “A review of the in vivo and in vitro toxicity of silver and gold particulates: particle attributes and biological mechanisms responsible for the observed toxicity,” Critical Reviews in Toxicology, vol. 40, no. 4, pp. 328–346, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. J. J. Li, S. Muralikrishnan, C. T. Ng, L. Y. Yung, and B. H. Bay, “Nanoparticle-induced pulmonary toxicity,” Experimental Biology and Medicine, vol. 235, no. 9, pp. 1025–1033, 2010.
  13. Z. Zhang, A. Berg, H. Levanon, R. W. Fessenden, and D. Meisel, “On the interactions of free radicals with gold nanoparticles,” Journal of the American Chemical Society, vol. 125, no. 26, pp. 7959–7963, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. I. M. Kennedy, D. Wilson, and A. I. Barakat, “Uptake and inflammatory effects of nanoparticles in a human vascular endothelial cell line,” Research Report, no. 136, pp. 3–32, 2009. View at Scopus
  15. H. Lee, D. Shin, H. Song et al., “Nanoparticles up-regulate tumor necrosis factor-α and CXCL8 via reactive oxygen species and mitogen-activated protein kinase activation,” Toxicology and Applied Pharmacology, vol. 238, no. 2, pp. 160–169, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. C. Buzea, I. I. Pacheco, and K. Robbie, “Nanomaterials and nanoparticles: sources and toxicity,” Biointerphases, vol. 2, no. 4, pp. MR17–MR71, 2007.
  17. B. Fubini and A. Hubbard, “Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis,” Free Radical Biology and Medicine, vol. 34, no. 12, pp. 1507–1516, 2003. View at Publisher · View at Google Scholar · View at Scopus
  18. X. He, S. Young, D. Schwegler-Berry, W. P. Chisholm, J. E. Fernback, and Q. Ma, “Multiwalled carbon nanotubes induce a fibrogenic response by stimulating reactive oxygen species production, activating NF-κB signaling, and promoting fibroblast-to-myofibroblast transformation,” Chemical Research in Toxicology, vol. 24, no. 12, pp. 2237–2248, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. L. Wang, R. R. Mercer, Y. Rojanasakul et al., “Direct fibrogenic effects of dispersed single-walled carbon nanotubes on human lung fibroblasts,” Journal of Toxicology and Environmental Health A, vol. 73, no. 5-6, pp. 410–422, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. V. Vallyathan and X. Shi, “The role of oxygen free radicals in occupational and environmental lung diseases,” Environmental Health Perspectives, vol. 105, supplement 1, pp. 165–177, 1997. View at Scopus
  21. V. J. Thannickal and B. L. Fanburg, “Reactive oxygen species in cell signaling,” American Journal of Physiology, vol. 279, no. 6, pp. L1005–L1028, 2000. View at Scopus
  22. L. Risom, P. Møller, and S. Loft, “Oxidative stress-induced DNA damage by particulate air pollution,” Mutation Research, vol. 592, no. 1-2, pp. 119–137, 2005. View at Publisher · View at Google Scholar · View at Scopus
  23. C. Huang, R. S. Aronstam, D. Chen, and Y. Huang, “Oxidative stress, calcium homeostasis, and altered gene expression in human lung epithelial cells exposed to ZnO nanoparticles,” Toxicology in Vitro, vol. 24, no. 1, pp. 45–55, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. H. Sies, “Oxidative stress: introduction,” in Oxidative Stress Oxidants and Antioxidants, H. Sies, Ed., pp. 15–22, Academic Press, London, UK, 1991.
  25. A. M. Knaapen, P. J. A. Borm, C. Albrecht, and R. P. F. Schins, “Inhaled particles and lung cancer, part A: mechanisms,” International Journal of Cancer, vol. 109, no. 6, pp. 799–809, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Valko, C. J. Rhodes, J. Moncol, M. Izakovic, and M. Mazur, “Free radicals, metals and antioxidants in oxidative stress-induced cancer,” Chemico-Biological Interactions, vol. 160, no. 1, pp. 1–40, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. K. Donaldson and C. L. Tran, “Inflammation caused by particles and fibers,” Inhalation Toxicology, vol. 14, no. 1, pp. 5–27, 2002. View at Publisher · View at Google Scholar · View at Scopus
  28. K. Donaldson, V. Stone, A. Clouter, L. Renwick, and W. MacNee, “Ultrafine particles,” Occupational and Environmental Medicine, vol. 58, no. 3, pp. 211–216, 2001. View at Publisher · View at Google Scholar · View at Scopus
  29. K. Donaldson, V. Stone, C. L. Tran, W. Kreyling, and P. J. A. Borm, “Nanotoxicology,” Occupational and Environmental Medicine, vol. 61, no. 9, pp. 727–728, 2004. View at Publisher · View at Google Scholar · View at Scopus
  30. A. Nel, “Air pollution-related illness: effects of particles,” Science, vol. 308, no. 5723, pp. 804–806, 2005. View at Publisher · View at Google Scholar · View at Scopus
  31. J. C. Bonner, “Lung fibrotic responses to particle exposure,” Toxicologic Pathology, vol. 35, no. 1, pp. 148–153, 2007. View at Publisher · View at Google Scholar · View at Scopus
  32. R. P. F. Schins, “Mechanisms of genotoxicity of particles and fibers,” Inhalation Toxicology, vol. 14, no. 1, pp. 57–78, 2002. View at Publisher · View at Google Scholar · View at Scopus
  33. G. Oberdörster, A. Maynard, K. Donaldson, et al., “Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy,” Particle and Fibre Toxicology, vol. 2, article 8, 2005.
  34. M. R. Wilson, J. H. Lightbody, K. Donaldson, J. Sales, and V. Stone, “Interactions between ultrafine particles and transition metals in vivo and in vitro,” Toxicology and Applied Pharmacology, vol. 184, no. 3, pp. 172–179, 2002. View at Publisher · View at Google Scholar · View at Scopus
  35. S. D. Aust, C. F. Chignell, T. M. Bray, B. Kalyanaraman, and R. P. Mason, “Free radicals in toxicology,” Toxicology and Applied Pharmacology, vol. 120, no. 2, pp. 168–178, 1993. View at Publisher · View at Google Scholar · View at Scopus
  36. K. R. Smith, L. R. Klei, and A. Barchowsky, “Arsenite stimulates plasma membrane NADPH oxidase in vascular endothelial cells,” American Journal of Physiology, vol. 280, no. 3, pp. L442–L449, 2001. View at Scopus
  37. C. Sioutas, R. J. Delfino, and M. Singh, “Exposure assessment for atmospheric Ultrafine Particles (UFPs) and implications in epidemiologic research,” Environmental Health Perspectives, vol. 113, no. 8, pp. 947–955, 2005. View at Publisher · View at Google Scholar · View at Scopus
  38. T. Xia, M. Kovochich, J. Brant et al., “Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm,” Nano Letters, vol. 6, no. 8, pp. 1794–1807, 2006. View at Publisher · View at Google Scholar · View at Scopus
  39. T. Coccini, S. Barni, R. Vaccarone, P. Mustarelli, L. Manzo, and E. Roda, “Pulmonary toxicity of instilled cadmium-doped silica nanoparticles during acute and subacute stages in rats,” Histology and Histopathology, vol. 28, no. 2, pp. 195–209, 2013.
  40. V. Stone, J. Shaw, D. M. Brown, W. Macnee, S. P. Faux, and K. Donaldson, “The role of oxidative stress in the prolonged inhibitory effect of ultrafine carbon black on epithelial cell function,” Toxicology in Vitro, vol. 12, no. 6, pp. 649–659, 1998. View at Publisher · View at Google Scholar · View at Scopus
  41. S. K. Sohaebuddin, P. T. Thevenot, D. Baker, J. W. Eaton, and L. Tang, “Nanomaterial cytotoxicity is composition, size, and cell type dependent,” Particle and Fibre Toxicology, vol. 7, article 22, 2010. View at Publisher · View at Google Scholar · View at Scopus
  42. V. K. Raghunathan, M. Devey, S. Hawkins, et al., “Influence of particle size and reactive oxygen species on cobalt chrome nanoparticle-mediated genotoxicity,” Biomaterials, vol. 34, no. 14, pp. 3559–3570, 2013.
  43. K. E. Driscoll, B. W. Howard, J. M. Carter, Y. M. W. Janssen, B. T. Mossman, and R. J. Isfort, “Mitochondrial-derived oxidants and quartz activation of chemokine gene expression,” Advances in Experimental Medicine and Biology, vol. 500, pp. 489–496, 2001. View at Scopus
  44. B. Fadeel and V. E. Kagan, “Apoptosis and macrophage clearance of neutrophils: regulation by reactive oxygen species,” Redox Report, vol. 8, no. 3, pp. 143–150, 2003. View at Publisher · View at Google Scholar · View at Scopus
  45. A. Deshpande, P. K. Narayanan, and B. E. Lehnert, “Silica-induced generation of extracellular factor(s) increases reactive oxygen species in human bronchial epithelial cells,” Toxicological Sciences, vol. 67, no. 2, pp. 275–283, 2002. View at Publisher · View at Google Scholar · View at Scopus
  46. I. Berg, T. Schluter, and G. Gercken, “Increase of bovine alveolar macrophage superoxide anion and hydrogen peroxide release by dusts of different origin,” Journal of Toxicology and Environmental Health, vol. 39, no. 3, pp. 341–354, 1993. View at Scopus
  47. W. A. Pryor, K. Stone, C. E. Cross, L. Machlin, and L. Packer, “Oxidants in cigarette smoke: radicals, hydrogen peroxide, peroxynitrate, and peroxynitrite,” Annals of the New York Academy of Sciences, vol. 686, pp. 12–28, 1993. View at Scopus
  48. V. Castranova, L. J. Huffman, D. J. Judy et al., “Enhancement of nitric oxide production by pulmonary cells following silica exposure,” Environmental Health Perspectives, vol. 106, supplement 5, pp. 1165–1169, 1998. View at Scopus
  49. J. M. Carter and K. E. Driscoll, “The role of inflammation, oxidative stress, and proliferation in silica-induced lung disease: a species comparison,” Journal of Environmental Pathology, Toxicology and Oncology, vol. 20, supplement 1, pp. 33–43, 2001. View at Scopus
  50. Y. Hsin, C. Chen, S. Huang, T. Shih, P. Lai, and P. J. Chueh, “The apoptotic effect of nanosilver is mediated by a ROS- and JNK-dependent mechanism involving the mitochondrial pathway in NIH3T3 cells,” Toxicology Letters, vol. 179, no. 3, pp. 130–139, 2008.
  51. P. J. A. Borm, D. Robbins, S. Haubold et al., “The potential risks of nanomaterials: a review carried out for ECETOC,” Particle and Fibre Toxicology, vol. 3, article 11, 2006. View at Publisher · View at Google Scholar · View at Scopus
  52. H. Eom and J. Choi, “p38 MAPK activation, DNA damage, cell cycle arrest and apoptosis as mechanisms of toxicity of silver nanoparticles in Jurkat T cells,” Environmental Science and Technology, vol. 44, no. 21, pp. 8337–8342, 2010. View at Publisher · View at Google Scholar · View at Scopus
  53. G. Lenaz, “The mitochondrial production of reactive oxygen species: mechanisms and implications in human pathology,” IUBMB Life, vol. 52, no. 3–5, pp. 159–164, 2001. View at Publisher · View at Google Scholar · View at Scopus
  54. J. F. Turrens, “Mitochondrial formation of reactive oxygen species,” Journal of Physiology, vol. 552, no. 2, pp. 335–344, 2003. View at Publisher · View at Google Scholar · View at Scopus
  55. J. Boonstra and J. A. Post, “Molecular events associated with reactive oxygen species and cell cycle progression in mammalian cells,” Gene, vol. 337, pp. 1–13, 2004. View at Publisher · View at Google Scholar · View at Scopus
  56. L. Wang, L. Bowman, Y. Lu et al., “Essential role of p53 in silica-induced apoptosis,” American Journal of Physiology, vol. 288, no. 3, pp. L488–L496, 2005. View at Publisher · View at Google Scholar · View at Scopus
  57. Y. Shi, F. Wang, J. He, S. Yadav, and H. Wang, “Titanium dioxide nanoparticles cause apoptosis in BEAS-2B cells through the caspase 8/t-Bid-independent mitochondrial pathway,” Toxicology Letters, vol. 196, no. 1, pp. 21–27, 2010. View at Publisher · View at Google Scholar · View at Scopus
  58. P. Manna, M. Ghosh, J. Ghosh, J. Das, and P. C. Sil, “Contribution of nano-copper particles to in vivo liver dysfunction and cellular damage: role of IκBα/NF-κB, MAPKs and mitochondrial signal,” Nanotoxicology, vol. 6, no. 1, pp. 1–21, 2012. View at Publisher · View at Google Scholar · View at Scopus
  59. X. Q. Zhang, L. H. Yin, M. Tang, and Y. P. Pu, “ZnO, TiO2, SiO2, and Al2O3 nanoparticles-induced toxic effects on human fetal lung fibroblasts,” Biomedical and Environmental Sciences, vol. 24, no. 6, pp. 661–669, 2011. View at Publisher · View at Google Scholar · View at Scopus
  60. M. Poljak-Blazi, M. Jaganjac, M. Mustapic, N. Pivac, and D. Muck-Seler, “Acute immunomodulatory effects of iron polyisomaltosate in rats,” Immunobiology, vol. 214, no. 2, pp. 121–128, 2009. View at Publisher · View at Google Scholar · View at Scopus
  61. S. Naqvi, M. Samim, M. Z. Abdin et al., “Concentration-dependent toxicity of iron oxide nanoparticles mediated by increased oxidative stress,” International Journal of Nanomedicine, vol. 5, no. 1, pp. 983–989, 2010. View at Publisher · View at Google Scholar · View at Scopus
  62. I. Pujalté, I. Passagne, B. Brouillaud et al., “Cytotoxicity and oxidative stress induced by different metallic nanoparticles on human kidney cells,” Particle and Fibre Toxicology, vol. 8, article 10, 2011. View at Publisher · View at Google Scholar · View at Scopus
  63. H. A. Jeng and J. Swanson, “Toxicity of metal oxide nanoparticles in mammalian cells,” Journal of Environmental Science and Health A, vol. 41, no. 12, pp. 2699–2711, 2006. View at Publisher · View at Google Scholar · View at Scopus
  64. E. Park, J. Choi, Y. Park, and K. Park, “Oxidative stress induced by cerium oxide nanoparticles in cultured BEAS-2B cells,” Toxicology, vol. 245, no. 1-2, pp. 90–100, 2008. View at Publisher · View at Google Scholar · View at Scopus
  65. A. Kumar, A. K. Pandey, S. S. Singh, R. Shanker, and A. Dhawan, “Engineered ZnO and TiO2 nanoparticles induce oxidative stress and DNA damage leading to reduced viability of Escherichia coli,” Free Radical Biology and Medicine, vol. 51, no. 10, pp. 1872–1881, 2011. View at Publisher · View at Google Scholar · View at Scopus
  66. I. Kim, M. Baek, and S. Choi, “Comparative cytotoxicity of Al2O3, CeO2, TiO2and ZnO nanoparticles to human lung cells,” Journal of Nanoscience and Nanotechnology, vol. 10, no. 5, pp. 3453–3458, 2010. View at Publisher · View at Google Scholar · View at Scopus
  67. S. Kawanishi, Y. Hiraku, M. Murata, and S. Oikawa, “The role of metals in site-specific DNA damage with reference to carcinogenesis,” Free Radical Biology and Medicine, vol. 32, no. 9, pp. 822–832, 2002. View at Publisher · View at Google Scholar · View at Scopus
  68. H. Shi, L. G. Hudson, and K. J. Liu, “Oxidative stress and apoptosis in metal ion-induced carcinogenesis,” Free Radical Biology and Medicine, vol. 37, no. 5, pp. 582–593, 2004. View at Publisher · View at Google Scholar · View at Scopus
  69. H. Wiseman and B. Halliwell, “Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer,” Biochemical Journal, vol. 313, part 1, pp. 17–29, 1996. View at Scopus
  70. H. Xie, M. M. Mason, and J. P. Wise Sr., “Genotoxicity of metal nanoparticles,” Reviews on Environmental Health, vol. 26, no. 4, pp. 251–268, 2011. View at Publisher · View at Google Scholar · View at Scopus
  71. A. Pilger and H. W. Rüdiger, “8-Hydroxy-2′-deoxyguanosine as a marker of oxidative DNA damage related to occupational and environmental exposures,” International Archives of Occupational and Environmental Health, vol. 80, no. 1, pp. 1–15, 2006. View at Publisher · View at Google Scholar · View at Scopus
  72. A. Valavanidis, T. Vlachogianni, and C. Fiotakis, “8-hydroxy-2′-deoxyguanosine (8-OHdG): a critical biomarker of oxidative stress and carcinogenesis,” Journal of Environmental Science and Health C, vol. 27, no. 2, pp. 120–139, 2009. View at Scopus
  73. K. Inoue, H. Takano, R. Yanagisawa et al., “Effects of airway exposure to nanoparticles on lung inflammation induced by bacterial endotoxin in mice,” Environmental Health Perspectives, vol. 114, no. 9, pp. 1325–1330, 2006. View at Publisher · View at Google Scholar · View at Scopus
  74. K. E. Eblin, M. E. Bowen, D. W. Cromey et al., “Arsenite and monomethylarsonous acid generate oxidative stress response in human bladder cell culture,” Toxicology and Applied Pharmacology, vol. 217, no. 1, pp. 7–14, 2006. View at Publisher · View at Google Scholar · View at Scopus
  75. M. Song, Y. Li, H. Kasai, and K. Kawai, “Metal nanoparticle-induced micronuclei and oxidative DNA damage in mice,” Journal of Clinical Biochemistry and Nutrition, vol. 50, no. 3, pp. 211–216, 2012.
  76. P. J. Howden and S. P. Faux, “Fibre-induced lipid peroxidation leads to DNA adduct formation in Salmonella typhimurium TA104 and rat lung fibroblasts,” Carcinogenesis, vol. 17, no. 3, pp. 413–419, 1996. View at Publisher · View at Google Scholar · View at Scopus
  77. R. K. Shukla, V. Sharma, A. K. Pandey, S. Singh, S. Sultana, and A. Dhawan, “ROS-mediated genotoxicity induced by titanium dioxide nanoparticles in human epidermal cells,” Toxicology in Vitro, vol. 25, no. 1, pp. 231–241, 2011. View at Publisher · View at Google Scholar · View at Scopus
  78. D. Napierska, V. Rabolli, L. C. J. Thomassen et al., “Oxidative stress induced by pure and iron-doped amorphous silica nanoparticles in subtoxic conditions,” Chemical Research in Toxicology, vol. 25, no. 4, pp. 828–837, 2012. View at Publisher · View at Google Scholar · View at Scopus
  79. M. L. Turski and D. J. Thiele, “New roles for copper metabolism in cell proliferation, signaling, and disease,” The Journal of Biological Chemistry, vol. 284, no. 2, pp. 717–721, 2009. View at Publisher · View at Google Scholar · View at Scopus
  80. I. Rahman, S. K. Biswas, L. A. Jimenez, M. Torres, and H. J. Forman, “Glutathione, stress responses, and redox signaling in lung inflammation,” Antioxidants and Redox Signaling, vol. 7, no. 1-2, pp. 42–59, 2005. View at Publisher · View at Google Scholar · View at Scopus
  81. G. M. Habib, Z. Shi, and M. W. Lieberman, “Glutathione protects cells against arsenite-induced toxicity,” Free Radical Biology and Medicine, vol. 42, no. 2, pp. 191–201, 2007. View at Publisher · View at Google Scholar · View at Scopus
  82. K. Rahman, “Studies on free radicals, antioxidants, and co-factors,” Clinical Interventions in Aging, vol. 2, no. 2, pp. 219–236, 2007. View at Scopus
  83. I. Fenoglio, I. Corazzari, C. Francia, S. Bodoardo, and B. Fubini, “The oxidation of glutathione by cobalt/tungsten carbide contributes to hard metal-induced oxidative stress,” Free Radical Research, vol. 42, no. 8, pp. 737–745, 2008. View at Publisher · View at Google Scholar · View at Scopus
  84. C. Stambe, R. C. Atkins, G. H. Tesch, T. Masaki, G. F. Schreiner, and D. J. Nikolic-Paterson, “The role of p38alpha mitogen-activated protein kinase activation in renal fibrosis,” Journal of the American Society of Nephrology, vol. 15, no. 2, pp. 370–379, 2004. View at Publisher · View at Google Scholar · View at Scopus
  85. E. Park, J. Yoon, K. Choi, J. Yi, and K. Park, “Induction of chronic inflammation in mice treated with titanium dioxide nanoparticles by intratracheal instillation,” Toxicology, vol. 260, no. 1–3, pp. 37–46, 2009. View at Publisher · View at Google Scholar · View at Scopus
  86. C. Moon, H. Park, Y. Choi, E. Park, V. Castranova, and J. L. Kang, “Pulmonary inflammation after intraperitoneal administration of ultrafine titanium dioxide (TiO2) at rest or in lungs primed with lipopolysaccharide,” Journal of Toxicology and Environmental Health A, vol. 73, no. 5-6, pp. 396–409, 2010. View at Publisher · View at Google Scholar · View at Scopus
  87. M. A. Maurer-Jones, Y. Lin, and C. L. Haynes, “Functional assessment of metal oxide nanoparticle toxicity in immune cells,” ACS Nano, vol. 4, no. 6, pp. 3363–3373, 2010. View at Publisher · View at Google Scholar · View at Scopus
  88. M. Zhu, W. Feng, Y. Wang et al., “Particokinetics and extrapulmonary translocation of intratracheally instilled ferric oxide nanoparticles in rats and the potential health risk assessment,” Toxicological Sciences, vol. 107, no. 2, pp. 342–351, 2009. View at Publisher · View at Google Scholar · View at Scopus
  89. C. Lam, J. T. James, R. McCluskey, and R. L. Hunter, “Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intractracheal instillation,” Toxicological Sciences, vol. 77, no. 1, pp. 126–134, 2004. View at Publisher · View at Google Scholar · View at Scopus
  90. A. A. Shvedova, E. R. Kisin, R. Mercer et al., “Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice,” American Journal of Physiology, vol. 289, no. 5, pp. L698–L708, 2005. View at Publisher · View at Google Scholar · View at Scopus
  91. A. A. Shvedova, E. Kisin, A. R. Murray et al., “Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesis,” American Journal of Physiology, vol. 295, no. 4, pp. L552–L565, 2008. View at Publisher · View at Google Scholar · View at Scopus
  92. K. Pulskamp, S. Diabaté, and H. F. Krug, “Carbon nanotubes show no sign of acute toxicity but induce intracellular reactive oxygen species in dependence on contaminants,” Toxicology Letters, vol. 168, no. 1, pp. 58–74, 2007. View at Publisher · View at Google Scholar · View at Scopus
  93. M. Pacurari, X. J. Yin, J. Zhao et al., “Raw single-wall carbon nanotubes induce oxidative stress and activate MAPKs, AP-1, NF-κB, and Akt in normal and malignant human mesothelial cells,” Environmental Health Perspectives, vol. 116, no. 9, pp. 1211–1217, 2008. View at Publisher · View at Google Scholar · View at Scopus
  94. J. L. Ingram, A. B. Rice, J. Santos, B. Van Houten, and J. C. Bonner, “Vanadium-induced HB-EGF expression in human lung fibroblasts is oxidant dependent and requires MAP kinases,” American Journal of Physiology, vol. 284, no. 5, pp. L774–L782, 2003. View at Scopus
  95. J. M. Antonini, “Health effects of welding,” Critical Reviews in Toxicology, vol. 33, no. 1, pp. 61–103, 2003. View at Scopus
  96. P. D. Blanc, H. A. Boushey, H. Wong, S. F. Wintermeyer, and M. S. Bernstein, “Cytokines in metal fume fever,” American Review of Respiratory Disease, vol. 147, no. 1, pp. 134–138, 1993. View at Scopus
  97. M. D. Taylor, J. R. Roberts, S. S. Leonard, X. Shi, and J. M. Antonini, “Effects of welding fumes of differing composition and solubility on free radical production and acute lung injury and inflammation in rats,” Toxicological Sciences, vol. 75, no. 1, pp. 181–191, 2003. View at Publisher · View at Google Scholar · View at Scopus
  98. M. Genestra, “Oxyl radicals, redox-sensitive signalling cascades and antioxidants,” Cellular Signalling, vol. 19, no. 9, pp. 1807–1819, 2007. View at Publisher · View at Google Scholar · View at Scopus
  99. J. Ye, X. Zhang, H. A. Young, Y. Mao, and X. Shi, “Chromium(VI)-induced nuclear factor-κB activation in intact cells via free radical reactions,” Carcinogenesis, vol. 16, no. 10, pp. 2401–2405, 1995. View at Scopus
  100. R. G. Allen and M. Tresini, “Oxidative stress and gene regulation,” Free Radical Biology and Medicine, vol. 28, no. 3, pp. 463–499, 2000. View at Publisher · View at Google Scholar · View at Scopus
  101. J. D. Byrne and J. A. Baugh, “The significance of nanoparticles in particle-induced pulmonary fibrosis,” McGill Journal of Medicine, vol. 11, no. 1, pp. 43–50, 2008. View at Scopus
  102. A. R. Murray, E. R. Kisin, A. V. Tkach et al., “Factoring-in agglomeration of carbon nanotubes and nanofibers for better prediction of their toxicity versus asbestos,” Particle and Fibre Toxicology, vol. 9, article 10, 2012. View at Publisher · View at Google Scholar · View at Scopus
  103. A. K. Hubbard, C. R. Timblin, A. Shukla, M. Rincón, and B. T. Mossman, “Activation of NF-κB-dependent gene expression by silica in lungs of luciferase reporter mice,” American Journal of Physiology, vol. 282, no. 5, pp. L968–L975, 2002. View at Scopus
  104. M. Ding, X. Shi, Y. Lu et al., “Induction of activator protein-1 through reactive oxygen species by crystalline silica in JB6 cells,” The Journal of Biological Chemistry, vol. 276, no. 12, pp. 9108–9114, 2001. View at Publisher · View at Google Scholar · View at Scopus
  105. K. Z. Guyton, Y. Liu, M. Gorospe, Q. Xu, and N. J. Holbrook, “Activation of mitogen-activated protein kinase by H2O2: role in cell survival following oxidant injury,” The Journal of Biological Chemistry, vol. 271, no. 8, pp. 4138–4142, 1996. View at Scopus
  106. C. Tournier, G. Thomas, J. Pierre, C. Jacquemin, M. Pierre, and B. Saunier, “Mediation by arachidonic acid metabolites of the H2O2-induced stimulation of mitogen-activated protein kinases (extracellular-signal-regulated kinase and c-Jun NH2-terminal kinase),” European Journal of Biochemistry, vol. 244, no. 2, pp. 587–595, 1997. View at Scopus
  107. Y. Son, Y. Cheong, N. Kim, H. Chung, D. G. Kang, and H. Pae, “Mitogen-activated protein kinases and reactive oxygen species: how can ROS activate MAPK pathways?” Journal of Signal Transduction, vol. 2011, Article ID 792639, 6 pages, 2011. View at Publisher · View at Google Scholar
  108. D. M. Barrett, S. M. Black, H. Todor, R. K. Schmidt-Ullrich, K. S. Dawson, and R. B. Mikkelsen, “Inhibition of protein-tyrosine phosphatases by mild oxidative stresses is dependent on S-nitrosylation,” The Journal of Biological Chemistry, vol. 280, no. 15, pp. 14453–14461, 2005. View at Publisher · View at Google Scholar · View at Scopus
  109. Y. Kim, W. Reed, W. Wu, P. A. Bromberg, L. M. Graves, and J. M. Samet, “Zn2+-induced IL-8 expression involves AP-1, JNK, and ERK activities in human airway epithelial cells,” American Journal of Physiology, vol. 290, no. 5, pp. L1028–L1035, 2006. View at Publisher · View at Google Scholar · View at Scopus
  110. T. L. Tal, L. M. Graves, R. Silbajoris, P. A. Bromberg, W. Wu, and J. M. Samet, “Inhibition of protein tyrosine phosphatase activity mediates epidermal growth factor receptor signaling in human airway epithelial cells exposed to Zn2+,” Toxicology and Applied Pharmacology, vol. 214, no. 1, pp. 16–23, 2006. View at Publisher · View at Google Scholar · View at Scopus
  111. F. Esposito, G. Chirico, N. M. Gesualdi et al., “Protein kinase B activation by reactive oxygen species is independent of tyrosine kinase receptor phosphorylation and requires Src activity,” The Journal of Biological Chemistry, vol. 278, no. 23, pp. 20828–20834, 2003. View at Publisher · View at Google Scholar · View at Scopus
  112. K. Balamurugan, R. Rajaram, T. Ramasami, and S. Narayanan, “Chromium(III)-induced apoptosis of lymphocytes: death decision by ROS and Src-family tyrosine kinases,” Free Radical Biology and Medicine, vol. 33, no. 12, pp. 1622–1640, 2002. View at Publisher · View at Google Scholar · View at Scopus
  113. British Standard Institute (BSI), “Nanotechnologies—part 2: guide to safe handling and disposal of manufactured nanomaterials,” Tech. Rep. PD, 6699-2, British Standard Institute (BSI), London, UK, 2007.
  114. T. Xia, M. Kovochich, M. Liong, J. I. Zink, and A. E. Nel, “Cationic polystyrene nanosphere toxicity depends on cell-specific endocytic and mitochondrial injury pathways,” ACS Nano, vol. 2, no. 1, pp. 85–96, 2008. View at Publisher · View at Google Scholar · View at Scopus
  115. A. Le Goff, M. Holzinger, and S. Cosnier, “Enzymatic biosensors based on SWCNT-conducting polymer electrodes,” Analyst, vol. 136, no. 7, pp. 1279–1287, 2011. View at Publisher · View at Google Scholar · View at Scopus
  116. D. B. Warheit, B. R. Laurence, K. L. Reed, D. H. Roach, G. A. M. Reynolds, and T. R. Webb, “Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats,” Toxicological Sciences, vol. 77, no. 1, pp. 117–125, 2004. View at Publisher · View at Google Scholar · View at Scopus
  117. J. C. Bonner, “The epidermal growth factor receptor at the crossroads of airway remodeling,” American Journal of Physiology, vol. 283, no. 3, pp. L528–L530, 2002. View at Scopus
  118. N. Azad, A. K. Iyer, L. Wang, Y. Liu, Y. Lu, and Y. Rojanasakul, “Reactive oxygen species-mediated p38 MAPK regulates carbon nanotube-induced fibrogenic and angiogenic responses,” Nanotoxicology, vol. 7, no. 2, pp. 157–168, 2012.
  119. S. K. Manna, S. Sarkar, J. Barr et al., “Single-walled carbon nanotube induces oxidative stress and activates nuclear transcription factor-κB in human keratinocytes,” Nano Letters, vol. 5, no. 9, pp. 1676–1684, 2005. View at Publisher · View at Google Scholar · View at Scopus
  120. A. A. Shvedova, A. A. Kapralov, W. H. Feng et al., “Impaired clearance and enhanced pulmonary inflammatory/fibrotic response to carbon nanotubes in myeloperoxidase-deficient mice,” PLoS ONE, vol. 7, no. 3, Article ID e30923, 2012. View at Publisher · View at Google Scholar · View at Scopus
  121. A. R. Reddy, D. R. Krishna, Y. N. Reddy, and V. Himabindu, “Translocation and extra pulmonary toxicities of multi wall carbon nanotubes in rats,” Toxicology Mechanisms and Methods, vol. 20, no. 5, pp. 267–272, 2010. View at Publisher · View at Google Scholar · View at Scopus
  122. L. A. Mitchell, J. Gao, R. V. Wal, A. Gigliotti, S. W. Burchiel, and J. D. McDonald, “Pulmonary and systemic immune response to inhaled multiwalled carbon nanotubes,” Toxicological Sciences, vol. 100, no. 1, pp. 203–214, 2007. View at Publisher · View at Google Scholar · View at Scopus
  123. S. Clichici, A. R. Biris, F. Tabaran, and A. Filip, “Transient oxidative stress and inflammation after intraperitoneal administration of multiwalled carbon nanotubes functionalized with single strand DNA in rats,” Toxicology and Applied Pharmacology, vol. 259, no. 3, pp. 281–292, 2012. View at Publisher · View at Google Scholar · View at Scopus
  124. K. Donaldson and C. A. Poland, “Inhaled nanoparticles and lung cancer—what we can learn from conventional particle toxicology,” Swiss Medical Weekly, vol. 142, Article ID w13547, 2012.
  125. M. Pacurari, Y. Qian, D. W. Porter et al., “Multi-walled carbon nanotube-induced gene expression in the mouse lung: association with lung pathology,” Toxicology and Applied Pharmacology, vol. 255, no. 1, pp. 18–31, 2011. View at Publisher · View at Google Scholar · View at Scopus
  126. M. C. Jaurand, “Mechanisms of fiber-induced genotoxicity,” Environmental Health Perspectives, vol. 105, supplement 5, pp. 1073–1084, 1997. View at Scopus
  127. M. F. Jaurand, A. Renier, and J. Daubriac, “Mesothelioma: do asbestos and carbon nanotubes pose the same health risk?” Particle and Fibre Toxicology, vol. 6, article 16, 2009. View at Publisher · View at Google Scholar · View at Scopus
  128. A. K. Patlolla, S. M. Hussain, J. J. Schlager, S. Patlolla, and P. B. Tchounwou, “Comparative study of the clastogenicity of functionalized and nonfunctionalized multiwalled carbon nanotubes in bone marrow cells of Swiss-Webster mice,” Environmental Toxicology, vol. 25, no. 6, pp. 608–621, 2010. View at Publisher · View at Google Scholar · View at Scopus
  129. A. Patlolla, B. Knighten, and P. Tchounwou, “Multi-walled carbon nanotubes induce cytotoxicity, genotoxicity and apoptosis in normal human dermal fibroblast cells,” Ethnicity & Disease, vol. 20, supplement 1, pp. 65–72, 2010. View at Scopus
  130. E. R. Kisin, A. R. Murray, L. Sargent et al., “Genotoxicity of carbon nanofibers: are they potentially more or less dangerous than carbon nanotubes or asbestos?” Toxicology and Applied Pharmacology, vol. 252, no. 1, pp. 1–10, 2011. View at Publisher · View at Google Scholar · View at Scopus
  131. E. R. Kisin, A. R. Murray, M. J. Keane et al., “Single-walled carbon nanotubes: geno- and cytotoxic effects in lung fibroblast V79 cells,” Journal of Toxicology and Environmental Health A, vol. 70, no. 24, pp. 2071–2079, 2007. View at Publisher · View at Google Scholar · View at Scopus
  132. D. van Berlo, M. J. Clift, C. Albrecht, and R. P. Schins, “Carbon nanotubes: an insight into the mechanisms of their potential genotoxicity,” Swiss Medical Weekly, vol. 142, Article ID w13698, 2012.
  133. Y. Guo, J. Zhang, Y. Zheng, J. Yang, and X. Zhu, “Cytotoxic and genotoxic effects of multi-wall carbon nanotubes on human umbilical vein endothelial cells in vitro,” Mutation Research, vol. 721, no. 2, pp. 184–191, 2011. View at Publisher · View at Google Scholar · View at Scopus
  134. A. R. N. Reddy, M. V. Rao, D. R. Krishna, V. Himabindu, and Y. N. Reddy, “Evaluation of oxidative stress and anti-oxidant status in rat serum following exposure of carbon nanotubes,” Regulatory Toxicology and Pharmacology, vol. 59, no. 2, pp. 251–257, 2011. View at Publisher · View at Google Scholar · View at Scopus
  135. F. Zhou, D. Xing, B. Wu, S. Wu, Z. Ou, and W. R. Chen, “New insights of transmembranal mechanism and subcellular localization of noncovalently modified single-walled carbon nanotubes,” Nano Letters, vol. 10, no. 5, pp. 1677–1681, 2010. View at Publisher · View at Google Scholar · View at Scopus
  136. P. Ravichandran, S. Baluchamy, B. Sadanandan et al., “Multiwalled carbon nanotubes activate NF-κB and AP-1 signaling pathways to induce apoptosis in rat lung epithelial cells,” Apoptosis, vol. 15, no. 12, pp. 1507–1516, 2010. View at Publisher · View at Google Scholar · View at Scopus
  137. J. Muller, I. Decordier, P. H. Hoet et al., “Clastogenic and aneugenic effects of multi-wall carbon nanotubes in epithelial cells,” Carcinogenesis, vol. 29, no. 2, pp. 427–433, 2008. View at Publisher · View at Google Scholar · View at Scopus
  138. T. Kisseleva and D. A. Brenner, “Mechanisms of fibrogenesis,” Experimental Biology and Medicine, vol. 233, no. 2, pp. 109–122, 2008. View at Publisher · View at Google Scholar · View at Scopus
  139. X. He, S. Young, J. E. Fernback, and Q. Ma, “Single-walled carbon nanotubes induce fibrogenic effect by disturbing mitochondrial oxidative stress and activating NF-κB signaling,” Journal of Clinical Toxicology, supplement S5, article 005, 2012.
  140. C. R. Keenan, R. Goth-Goldstein, D. Lucas, and D. L. Sedlak, “Oxidative stress induced by zero-valent iron nanoparticles and Fe(II) in human bronchial epithelial cells,” Environmental Science and Technology, vol. 43, no. 12, pp. 4555–4560, 2009. View at Publisher · View at Google Scholar · View at Scopus
  141. P. L. Apopa, Y. Qian, R. Shao et al., “Iron oxide nanoparticles induce human microvascular endothelial cell permeability through reactive oxygen species production and microtubule remodeling,” Particle and Fibre Toxicology, vol. 6, article 1, 2009. View at Publisher · View at Google Scholar · View at Scopus
  142. A. R. Murray, E. Kisin, A. Inman, et al., “Oxidative stress and dermal toxicity of iron oxide nanoparticles in vitro,” Cell Biochemistry and Biophysics. In press.
  143. M. Ahamed, M. A. Siddiqui, M. J. Akhtar, I. Ahmad, A. B. Pant, and H. A. Alhadlaq, “Genotoxic potential of copper oxide nanoparticles in human lung epithelial cells,” Biochemical and Biophysical Research Communications, vol. 396, no. 2, pp. 578–583, 2010. View at Publisher · View at Google Scholar · View at Scopus
  144. H. L. Karlsson, J. Gustafsson, P. Cronholm, and L. Möller, “Size-dependent toxicity of metal oxide particles—a comparison between nano- and micrometer size,” Toxicology Letters, vol. 188, no. 2, pp. 112–118, 2009. View at Publisher · View at Google Scholar · View at Scopus
  145. B. Fahmy and S. A. Cormier, “Copper oxide nanoparticles induce oxidative stress and cytotoxicity in airway epithelial cells,” Toxicology in Vitro, vol. 23, no. 7, pp. 1365–1371, 2009. View at Publisher · View at Google Scholar · View at Scopus
  146. R. Lei, C. Wu, B. Yang et al., “Integrated metabolomic analysis of the nano-sized copper particle-induced hepatotoxicity and nephrotoxicity in rats: a rapid in vivo screening method for nanotoxicity,” Toxicology and Applied Pharmacology, vol. 232, no. 2, pp. 292–301, 2008. View at Publisher · View at Google Scholar · View at Scopus
  147. J. Y. Ma, H. Zhao, R. R. Mercer et al., “Cerium oxide nanoparticle-induced pulmonary inflammation and alveolar macrophage functional change in rats,” Nanotoxicology, vol. 5, no. 3, pp. 312–325, 2011. View at Publisher · View at Google Scholar · View at Scopus
  148. H. Eom and J. Choi, “Oxidative stress of CeO2 nanoparticles via p38-Nrf-2 signaling pathway in human bronchial epithelial cell, Beas-2B,” Toxicology Letters, vol. 187, no. 2, pp. 77–83, 2009. View at Publisher · View at Google Scholar · View at Scopus
  149. W. Lin, Y. Huang, X. Zhou, and Y. Ma, “Toxicity of cerium oxide nanoparticles in human lung cancer cells,” International Journal of Toxicology, vol. 25, no. 6, pp. 451–457, 2006. View at Publisher · View at Google Scholar · View at Scopus
  150. T. Xia, M. Kovochich, M. Liong et al., “Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties,” ACS Nano, vol. 2, no. 10, pp. 2121–2134, 2008. View at Publisher · View at Google Scholar · View at Scopus
  151. B. De Berardis, G. Civitelli, M. Condello et al., “Exposure to ZnO nanoparticles induces oxidative stress and cytotoxicity in human colon carcinoma cells,” Toxicology and Applied Pharmacology, vol. 246, no. 3, pp. 116–127, 2010. View at Publisher · View at Google Scholar · View at Scopus
  152. V. Sharma, D. Anderson, and A. Dhawan, “Zinc oxide nanoparticles induce oxidative DNA damage and ROS-triggered mitochondria mediated apoptosis in human liver cells (HepG2),” Apoptosis, vol. 17, no. 8, pp. 852–870, 2012. View at Publisher · View at Google Scholar · View at Scopus
  153. S. Alarifi, D. Ali, S. Alkahtani, et al., “Induction of oxidative stress, DNA damage, and apoptosis in a malignant human skin melanoma cell line after exposure to zinc oxide nanoparticles,” International Journal of Nanomedicine, vol. 8, pp. 983–993, 2013.
  154. D. Guo, H. Bi, B. Liu, Q. Wu, D. Wang, and Y. Cui, “Reactive oxygen species-induced cytotoxic effects of zinc oxide nanoparticles in rat retinal ganglion cells,” Toxicology in Vitro, vol. 27, no. 2, pp. 731–738, 2013.
  155. M. Ahamed, M. J. Akhtar, M. Raja et al., “ZnO nanorod-induced apoptosis in human alveolar adenocarcinoma cells via p53, survivin and bax/bcl-2 pathways: role of oxidative stress,” Nanomedicine, vol. 7, no. 6, pp. 904–913, 2011. View at Publisher · View at Google Scholar · View at Scopus
  156. Y. Ye, J. Liu, J. Xu, L. Sun, M. Chen, and M. Lan, “Nano-SiO2 induces apoptosis via activation of p53 and Bax mediated by oxidative stress in human hepatic cell line,” Toxicology in Vitro, vol. 24, no. 3, pp. 751–758, 2010. View at Publisher · View at Google Scholar · View at Scopus
  157. Y. Ye, J. Liu, M. Chen, L. Sun, and M. Lan, “In vitro toxicity of silica nanoparticles in myocardial cells,” Environmental Toxicology and Pharmacology, vol. 29, no. 2, pp. 131–137, 2010. View at Publisher · View at Google Scholar · View at Scopus
  158. F. Wang, F. Gao, M. Lan, H. Yuan, Y. Huang, and J. Liu, “Oxidative stress contributes to silica nanoparticle-induced cytotoxicity in human embryonic kidney cells,” Toxicology in Vitro, vol. 23, no. 5, pp. 808–815, 2009. View at Publisher · View at Google Scholar · View at Scopus
  159. Q. Chen, Y. Xue, and J. Sun, “Kupffer cell-mediated hepatic injury induced by silica nanoparticles in vitro and in vivo,” International Journal of Nanomedicine, vol. 8, pp. 1129–1140, 2013.
  160. M. A. Siddiqui, M. Ahamed, J. Ahmad et al., “Nickel oxide nanoparticles induce cytotoxicity, oxidative stress and apoptosis in cultured human cells that is abrogated by the dietary antioxidant curcumin,” Food and Chemical Toxicology, vol. 50, no. 3-4, pp. 641–647, 2012. View at Publisher · View at Google Scholar · View at Scopus
  161. M. Ahamed, M. J. Akhtar, M. A. Siddiqui et al., “Oxidative stress mediated apoptosis induced by nickel ferrite nanoparticles in cultured A549 cells,” Toxicology, vol. 283, no. 2-3, pp. 101–108, 2011. View at Publisher · View at Google Scholar · View at Scopus
  162. K. C. Yoo, C. H. Yoon, D. Kwon, K. H. Hyun, S. J. Woo, R. K. Kim, et al., “Titanium dioxide induces apoptotic cell death through reactive oxygen species-mediated fas upregulation and bax activation,” International Journal of Nanomedicine, vol. 7, pp. 1203–1214, 2012.
  163. Q. Saquib, A. A. Al-Khedhairy, M. A. Siddiqui, F. M. Abou-Tarboush, A. Azam, and J. Musarrat, “Titanium dioxide nanoparticles induced cytotoxicity, oxidative stress and DNA damage in human amnion epithelial (WISH) cells,” Toxicology in Vitro, vol. 26, no. 2, pp. 351–361, 2012. View at Publisher · View at Google Scholar · View at Scopus
  164. K. M. Ramkumar, C. Manjula, G. GnanaKumar et al., “Oxidative stress-mediated cytotoxicity and apoptosis induction by TiO2 nanofibers in HeLa cells,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 81, no. 2, pp. 324–333, 2012. View at Publisher · View at Google Scholar · View at Scopus
  165. A. A. Alshatwi, P. V. Subbarayan, E. Ramesh, A. A. Al-Hazzani, M. A. Alsaif, and A. A. Alwarthan, “Aluminium oxide nanoparticles induce mitochondrial-mediated oxidative stress and alter the expression of antioxidant enzymes in human mesenchymal stem cells,” Food Additives and Contaminants A, vol. 30, no. 1, pp. 1–10, 2013.
  166. J. J. Li, D. Hartono, C. Ong, B. Bay, and L. L. Yung, “Autophagy and oxidative stress associated with gold nanoparticles,” Biomaterials, vol. 31, no. 23, pp. 5996–6003, 2010. View at Publisher · View at Google Scholar · View at Scopus
  167. P. V. AshaRani, G. L. K. Mun, M. P. Hande, and S. Valiyaveettil, “Cytotoxicity and genotoxicity of silver nanoparticles in human cells,” ACS Nano, vol. 3, no. 2, pp. 279–290, 2009. View at Publisher · View at Google Scholar · View at Scopus
  168. P. Chairuangkitti, S. Lawanprasert, S. Roytrakul, S. Aueviriyavit, D. Phummiratch, K. Kulthong, et al., “Silver nanoparticles induce toxicity in A549 cells via ROS-dependent and ROS-independent pathways,” Toxicology in Vitro, vol. 27, no. 1, pp. 330–338, 2013.
  169. I. Papageorgiou, C. Brown, R. Schins et al., “The effect of nano- and micron-sized particles of cobalt-chromium alloy on human fibroblasts in vitro,” Biomaterials, vol. 28, no. 19, pp. 2946–2958, 2007. View at Publisher · View at Google Scholar · View at Scopus
  170. A. A. Shvedova, V. Castranova, E. R. Kisin et al., “Exposure to carbon nanotube material: assessment of nanotube cytotoxicity using human keratinocyte cells,” Journal of Toxicology and Environmental Health A, vol. 66, no. 20, pp. 1909–1926, 2003. View at Scopus
  171. C. S. Sharma, S. Sarkar, A. Periyakaruppan et al., “Single-walled carbon nanotubes induces oxidative stress in rat lung epithelial cells,” Journal of Nanoscience and Nanotechnology, vol. 7, no. 7, pp. 2466–2472, 2007. View at Publisher · View at Google Scholar · View at Scopus
  172. A. R. Murray, E. Kisin, S. S. Leonard et al., “Oxidative stress and inflammatory response in dermal toxicity of single-walled carbon nanotubes,” Toxicology, vol. 257, no. 3, pp. 161–171, 2009. View at Publisher · View at Google Scholar · View at Scopus
  173. B. Chen, Y. Liu, W. M. Song, Y. Hayashi, X. C. Ding, and W. H. Li, “In vitro evaluation of cytotoxicity and oxidative stress induced by multiwalled carbon nanotubes in murine RAW 264.7 macrophages and human A549 Lung cells,” Biomedical and Environmental Sciences, vol. 24, no. 6, pp. 593–601, 2011. View at Publisher · View at Google Scholar · View at Scopus
  174. M. Pacurari, Y. Qian, W. Fu et al., “Cell permeability, migration, and reactive oxygen species induced by multiwalled carbon nanotubes in human microvascular endothelial cells,” Journal of Toxicology and Environmental Health A, vol. 75, no. 2, pp. 112–128, 2012. View at Publisher · View at Google Scholar · View at Scopus