Evaluation of Adverse Effects of Mutein Forms of Recombinant Human Interferon Alpha-2b in Female Swiss Webster Mice

Figure 3

Histological presentation after H/E staining of heart tissue of the mice treated with a single dose of subcutaneous wild type rIFN-α2b or rhIFN-α2bC₂DC₉₉D (magnification 400x). (a) Control; (b) wild type rhIFN-α2b (D1); (c) rhIFN-α2bC₂DC₉₉D (D1); (d) wild type rhIFN-α2b (D2); (e) rhIFN-α2bC₂DC₉₉D (D2); (f) wild type rhIFN-α2b (D3); (g) rhIFN-α2bC₂DC₉₉D (D3).

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