Evaluation of Adverse Effects of Mutein Forms of Recombinant Human Interferon Alpha-2b in Female Swiss Webster Mice

Figure 8

Histological presentation of H/E staining of liver tissue of the mice after subcutaneous administration of wild type rhIFN-α2b or rhIFN-α2bC₂DC₉₉D once every 3 days during a 45-day period (magnification 400x). (a) Control; (b) wild type rhIFN-α2b (D4); (c) rhIFN-α2bC₂DC₉₉D (D4); (d) wild type rhIFN-α2b (D5); (e) rhIFN-α2bC₂DC₉₉D (D5).

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