About this Journal Submit a Manuscript Table of Contents
BioMed Research International
Volume 2013 (2013), Article ID 943687, 11 pages
http://dx.doi.org/10.1155/2013/943687
Research Article

Evaluation of Adverse Effects of Mutein Forms of Recombinant Human Interferon Alpha-2b in Female Swiss Webster Mice

1Research group of Pharmaceutics, School of Pharmacy, Bandung Institute of Technology, Ganesha 10, Bandung 40132, Indonesia
2Research group of Pharmacology and Clinical Pharmacy, School of Pharmacy, Bandung Institute of Technology, Bandung 40132, Indonesia

Received 3 December 2012; Accepted 30 March 2013

Academic Editor: Ayman El-Kadi

Copyright © 2013 H. Rachmawati et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. W. Shepard, L. Finelli, and M. J. Alter, “Global epidemiology of hepatitis C virus infection,” Lancet Infectious Diseases, vol. 5, no. 9, pp. 558–567, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. T. Utsumi, Y. Yano, M. I. Lusida et al., “Serologic and molecular characteristics of hepatitis B virus among school children in East Java, Indonesia,” American Journal of Tropical Medicine and Hygiene, vol. 83, no. 1, pp. 189–193, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. H. B. El-Serag, “Epidemiology of hepatocellular carcinoma,” Clinics in Liver Disease, vol. 5, no. 1, pp. 87–107, 2001. View at Scopus
  4. V. Fensterl and G. C. Sen, “Interferons and viral infections,” BioFactors, vol. 35, no. 1, pp. 14–20, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. B. Gao, F. Hong, and S. Radaeva, “Host factors and failure of interferon-α treatment in Hepatitis C virus,” Hepatology, vol. 39, no. 4, pp. 880–890, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. P. J. Gow and D. Mutimer, “Treatment of chronic hepatitis,” British Medical Journal, vol. 323, pp. 1164–1167, 2001.
  7. E. Jonasch and F. G. Haluska, “Interferon in oncological practice: review of interferon biology, clinical applications, and toxicities,” Oncologist, vol. 6, no. 1, pp. 34–55, 2001. View at Publisher · View at Google Scholar · View at Scopus
  8. N. Ceaglio, M. Etcheverrigaray, R. Kratje, and M. Oggero, “Novel long-lasting interferon alpha derivatives designed by glycoengineering,” Biochimie, vol. 90, no. 3, pp. 437–449, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. R. Radhakrishnan, L. J. Walter, A. Hruza et al., “Zinc mediated dimer of human interferon-α(2b) revealed by X-ray crystallography,” Structure, vol. 4, no. 12, pp. 1453–1463, 1996. View at Scopus
  10. C. Weissmann and H. Weber, “The interferon genes,” Progress in Nucleic Acid Research & Molecular Biology, vol. 33, pp. 251–300, 1986.
  11. F. O. Neves, P. L. Ho, I. Raw, C. A. Pereira, C. Moreira, and A. L. T. O. Nascimento, “Overexpression of a synthetic gene encoding human alpha interferon in Escherichia coli,” Protein Expression and Purification, vol. 35, no. 2, pp. 353–359, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. D. S. Retnoningrum, R. A. Ningrum, Y. N. Kurniawan, A. Indrayati, and H. Rachmawati, “Construction of synthetic open reading frame encoding human interferon alpha 2b for high expression in Escherichia coli and characterization of its gene product,” Journal of Biotechnology, vol. 145, no. 2, pp. 193–198, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. R. A. Ningrum, D. S. Retnoningrum, Y. Cahyati, and H. Rachmawati, “Optimization of human interferon α2b soluble protein overproduction and primary recovery of its inclusion bodies,” Microbiology Indonesia, vol. 5, no. 1, pp. 27–32, 2011.
  14. R. A. Ningrum, D. E. Rahmatika, D. S. Retnoningrum, A. H. Wangsaatmadja, Y. C. Sumitrapura, and H. Rachmawati, “Development of novel interferon alpha 2b muteins and study the pharmacokinetic and biodistribution profiles in animal model,” Journal of Biomedical Science and Engineering, vol. 5, pp. 104–112, 2012.
  15. J. Meng, Z. Yan, Y. Wu et al., “Preclinical safety evaluation of IFNα2a-NGR,” Regulatory Toxicology and Pharmacology, vol. 50, no. 3, pp. 294–302, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. X. Hu, K. Olivier, E. Polack et al., “In vivo pharmacology and toxicology evaluation of polyethylene glycol-conjugated interferon beta-1a,” Journal of Pharmacology and Experimental Therapeutics, vol. 338, no. 3, pp. 984–996, 2011.
  17. J. Fioravanti, I. González, J. Medina-Echeverz et al., “Anchoring interferon alpha to apolipoprotein A-I reduces hematological toxicity while enhancing immunostimulatory properties,” Hepatology, vol. 53, no. 6, pp. 1864–1873, 2011. View at Publisher · View at Google Scholar · View at Scopus