Review Article
Hemizona Assay and Sperm Penetration Assay in the Prediction of IVF Outcome: A Systematic Review
Table 1
(a) Experimental parameters of studies investigating the validity of SPA. (b) Experimental parameters of studies investigating the validity of HZA.
(a) |
| Study group | Publication date | Study design | | Normal SP () | Abnormal SP () | Capacitation medium | Pre-incubation period |
| Margalioth et al. [23] | 1983 | Prospective | 20 | 20 | 0 | NR | NR | Wolf et al. [24] | 1983 | Prospective | 24 | 24 | 0 | Ham’s F-10 with 7,5% maternal serum | 3 hrs | Foreman et al. [25] | 1984 | Prospective | 22 | 14 | 8 | Earle’s with 8% HSA | 3 hrs | Ausmanas et al. [26] | 1985 | Prospective | 54 | 42 | 12 | BWW with 35 mg/mL HSA | 5 hrs | Belkien et al. [27] | 1985 | Prospective | 29 | 23 | 6 | Ham’s F-10 with 10% maternal serum | 6 hrs | Margalioth et al. [28] | 1986 | Prospective | 134 | 124 | 10 | mBWW with 35 mg/mL HSA | 18 hrs | Corson et al. [29] | 1987 | Prospective | 30 | 17 | 13 | BWW with 5 mg/mL HSA | 18–20 hrs | Kruger et al. [30] | 1988 | Retrospective | 84 | NR | NR | NR | NR | Coetzee et al. [31] | 1989 | Prospective | 71 | NR | NR | BWW | 18–20 hrs | Ibrahim et al. [32] | 1989 | Prospective | 59 | 35 | 24 | BWW with 3.5 mg/mL HSA | 3 hrs | Nahhas and Blumenfeld [33] | 1989 | Prospective | 31 | 27 | 4 | BWW with 36 mg/mL HSA | 18 hrs | McClure et al. [34] | 1990 | Prospective | 19 | 10 | 9 | BWW with 6 mg/mL HSA | 18 hrs | | | | | | | 0.4 mL of Human Follicular Fluid | 0.5 hrs | Soffer et al. [35] | 1992 | Follow-up | 241 | NR | NR | TEST yolk buffer | 18–22 hrs | Freeman et al. [36] | 2001 | Prospective | 216 | NR | NR | BWW with TEST yolk buffer | 18–20 hrs |
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Abbreviations: (number of participants/patients), SP (Semen Parameters), BWW (Biggers, Whitten and Whittingham medium), HSA (Human Serum Albumin), NR (Not Reported).
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(b) |
| Study group | Publication date | Study design | | Normal SP () | Abnormal SP () | Oocyte source | Oocyte preservation |
| Oehninger et al. [37] | 1989 | Prospective | 28 | 17 | 11 | SR ovarian tissue | Salt storage | Oehninger et al. [38] | 1991 | Prospective | 37 | 15 | 22 | IVF patient donation | Salt storage | Oehninger et al. [39] | 1992 | Prospective | 44 | 31 | 13 | SR ovarian tissue | Salt storage | Franken et al. [40] | 1993 | Prospective | 112 | 58 | 54 | SR ovarian tissue and IVF patient donation | Salt storage | Franken et al. [41] | 1993 | Prospective | 48 | 28 | 20 | SR ovarian tissue and IVF patient donation | Salt Storage | Gamzu et al. [42] | 1994 | Prospective | 65 | 47 | 18 | IVF patient donation | Salt Storage | Oehninger et al. [43] | 1997 | Prospective | 196 | 138 | 58 | SR ovarian tissue | Salt storage |
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Abbreviations: (number of participants/patients), SP (Semen Parameters), SR (Surgically Recovered).
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