Review Article
Hemizona Assay and Sperm Penetration Assay in the Prediction of IVF Outcome: A Systematic Review
Table 2
SPA and IVF outcome and summary of diagnostic accuracy findings.
| | Study group, date | SPA threshold (%) | Fertilization rate cut-off (%) | Sensitivity | Specificity | PPV | NPV |
| | Margalioth et al., 1983 [23] | ≥20 | >0 | 100% | 70% | 77% | 100% | | Wolf et al., 1983 [24] | ≥10 | >0 | 88% | 0% | 68% | 0% | | Foreman et al., 1984 [25] | >10 | >0 | 67% | 53% | 18% | 91% | | Ausmanas et al., 1985 [26] | >15 | >0 | 73% | 33% | 95% | 7% | | Belkien et al., 1985 [27] | >15 | >0 | 87% | 17% | 80% | 25% | | Margalioth et al., 1986 [28] | >20 | >0 | 94% | 57% | 85% | 78% | | Corson et al., 1987 [29] | ≥11 | >0 | 52% | 100% | 100% | 39% | | Kruger et al., 1988 [30] | >10 | >0 | 59% | 62% | 82% | 33% | | Coetzee et al., 1989 [31] | >10 | >0 | 65% | 85% | 95% | 35% | | Ibrahim et al., 1989 [32] | >17 | >0 | 74% | 84% | NR | NR | |
Nahhas and Blumenfeld, 1989 [33]
| >20 | >0 | 100% | 44% | 81% | 100% | | McClure et al. 1990 [34] | >10 | >0 | 93% | 75% | 93% | 75% | | Soffer et al., 1992 [35] | >20 | >0 | 96% | NR | 82% | 74% | | Freeman et al., 2001 [36] | ≥20 | >50 | 70% | 99% | 98% | 84% |
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Abbreviations: PPV (positive predictive value), NPV (negative predictive value), and NR (not reported).
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