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BioMed Research International
Volume 2013 (2013), Article ID 947072, 11 pages
Regulation of Tight Junctions in Upper Airway Epithelium
1Department of Pathology, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan
2Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan
3Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan
4Department of Microbiology, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan
Received 7 July 2012; Accepted 29 August 2012
Academic Editor: Mouldy Sioud
Copyright © 2013 Takashi Kojima et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- S. T. Holgate, “The airway epithelium is central to the pathogenesis of asthma,” Allergology International, vol. 57, no. 1, pp. 1–10, 2008.
- Y. Fujimura, “Evidence of M cells as portals of entry for antigens in the nasopharyngeal lymphoid tissue of humans,” Virchows Archiv, vol. 436, no. 6, pp. 560–566, 2000.
- D. Y. Kim, A. Sato, S. Fukuyama et al., “The airway antigen sampling system: respiratory M cells as an alternative gateway for inhaled antigens,” The Journal of Immunology, vol. 186, no. 7, pp. 4253–4262, 2011.
- M. C. Nawijn, T. L. Hackett, D. S. Postma, A. J. M. van Oosterhout, and I. H. Heijink, “E-cadherin: gatekeeper of airway mucosa and allergic sensitization,” Trends in Immunology, vol. 32, no. 6, pp. 248–255, 2011.
- K. I. Takano, T. Kojima, N. Ogasawara et al., “Expression of tight junction proteins in epithelium including Ck20-positive M-like cells of human adenoids in vivo and in vitro,” Journal of Molecular Histology, vol. 39, no. 3, pp. 265–273, 2008.
- R. M. Steinman, M. Pack, and K. Inaba, “Dendritic cells in the T-cell areas of lymphoid organs,” Immunological Reviews, vol. 156, pp. 25–37, 1997.
- T. Yamanaka, L. Helgeland, I. N. Farstad, H. Fukushima, T. Midtvedt, and P. Brandtzaeg, “Microbial colonization drives lymphocyte accumulation and differentiation in the follicle-associated epithelium of Peyer's patches,” The Journal of Immunology, vol. 170, no. 2, pp. 816–822, 2003.
- H. Hammad and B. N. Lambrecht, “Dendritic cells and airway epithelial cells at the interface between innate and adaptive immune responses,” Allergy, vol. 66, no. 5, pp. 579–587, 2011.
- S. T. Holgate, “Epithelium dysfunction in asthma,” Journal of Allergy and Clinical Immunology, vol. 120, no. 6, pp. 1233–1244, 2007.
- R. P. Schleimer, A. Kato, R. Kern, D. Kuperman, and P. C. Avila, “Epithelium: at the interface of innate andadaptive immune responses,” Journal of Allergy and Clinical Immunology, vol. 120, no. 6, pp. 1279–1284, 2007.
- B. M. Gumbiner, “Breaking through the tight junction barrier,” The Journal of Cell Biology, vol. 123, no. 6, part 2, pp. 1631–1633, 1993.
- E. E. Schneeberger and R. D. Lynch, “Structure, function, and regulation of cellular tight junctions,” American Journal of Physiology—Lung Cellular and Molecular Physiology, vol. 262, no. 6, pp. L647–L661, 1992.
- G. van Meer and K. Simons, “The function of tight junctions in maintaining differences in lipid composition between the apical and the basolateral cell surface domains of MDCK cells,” The EMBO journal, vol. 5, no. 7, pp. 1455–1464, 1986.
- M. Cereijido, J. Valdés, L. Shoshani, and R. G. Contreras, “Role of tight junctions in establishing and maintaining cell polarity,” Annual Review of Physiology, vol. 60, pp. 161–177, 1998.
- M. S. Balda and K. Matter, “Tight junctions and the regulation of gene expression,” Biochimica et Biophysica Acta, vol. 1788, no. 4, pp. 761–767, 2009.
- E. E. Schneeberger and R. D. Lynch, “The tight junction: a multifunctional complex,” American Journal of Physiology—Cell Physiology, vol. 286, no. 6, pp. C1213–C1228, 2004.
- S. Tsukita, M. Furuse, and M. Itoh, “Multifunctional strands in tight junctions,” Nature Reviews Molecular Cell Biology, vol. 2, no. 4, pp. 285–293, 2001.
- N. Sawada, M. Murata, K. Kikuchi et al., “Tight junctions and human diseases,” Medical Electron Microscopy, vol. 36, no. 3, pp. 147–156, 2003.
- J. M. Anderson, “Cell signalling: MAGUK magic,” Current Biology, vol. 6, no. 4, pp. 382–384, 1996.
- K. Umeda, J. Ikenouchi, S. Katahira-Tayama et al., “ZO-1 and ZO-2 independently determine where claudins are polymerized in tight-junction strand formation,” Cell, vol. 126, no. 4, pp. 741–754, 2006.
- J. Ikenouchi, M. Furuse, K. Furuse, H. Sasaki, S. Tsukita, and S. Tsukita, “Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells,” The Journal of Cell Biology, vol. 171, no. 6, pp. 939–945, 2005.
- S. Masuda, Y. Oda, H. Sasaki et al., “LSR defines cell corners for tricellular tight junction formation in epithelial cells,” Journal of Cell Science, vol. 124, no. 4, pp. 548–555, 2011.
- K. Mineta, Y. Yamamoto, Y. Yamazaki et al., “Predicted expansion of the claudin multigene family,” FEBS Letters, vol. 585, no. 4, pp. 606–612, 2011.
- L. W. Meredith, G. K. Wilson, N. F. Fletcher, and J. A. McKeating, “Hepatitis C virus entry: beyond receptors,” Reviews in Medical Virology, vol. 22, no. 3, pp. 182–193, 2012.
- S. M. Krug, D. Günzel, M. P. Conrad et al., “Charge-selective claudin channels,” Annals of the New York Academy Sciences, vol. 1257, no. 1, pp. 20–28, 2012.
- K. Fujita, J. Katahira, Y. Horiguchi, N. Sonoda, M. Furuse, and S. Tsukita, “Clostridium perfringens enterotoxin binds to the second extracellular loop of claudin-3, a tight junction integral membrane protein,” FEBS Letters, vol. 476, no. 3, pp. 258–261, 2000.
- J. Katahira, H. Sugiyama, N. Inoue, Y. Horiguchi, M. Matsuda, and N. Sugimoto, “Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo,” The Journal of Biological Chemistry, vol. 272, no. 42, pp. 26652–26658, 1997.
- P. Michl, M. Buchholz, M. Rolke et al., “Claudin-4: a new target for pancreatic cancer treatment using clostridium perfringens enterotoxin,” Gastroenterology, vol. 121, no. 3, pp. 678–684, 2001.
- R. Saeki, M. Kondoh, H. Kakutani et al., “A novel tumor-targeted therapy using a claudin-4-targeting molecule,” Molecular Pharmacology, vol. 76, no. 4, pp. 918–926, 2009.
- M. Furuse, T. Hirase, M. Itoh et al., “Occludin: a novel integral membrane protein localizing at tight junctions,” The Journal of Cell Biology, vol. 123, no. 6, pp. 1777–1788, 1993.
- M. S. Balda, J. A. Whitney, C. Flores, S. González, M. Cereijido, and K. Matter, “Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein,” The Journal of Cell Biology, vol. 134, no. 4, pp. 1031–1049, 1996.
- K. M. McCarthy, I. B. Skare, M. C. Stankewich et al., “Occludin is a functional component of the tight junction,” Journal of Cell Science, vol. 109, no. 9, pp. 2287–2298, 1996.
- T. Hirase, J. M. Staddon, M. Saitou et al., “Occludin as a possible determinant of tight junction permeability in endothelial cells,” Journal of Cell Science, vol. 110, no. 14, pp. 1603–1613, 1997.
- M. Saitou, K. Fujimoto, Y. Doi et al., “Occludin-deficient embryonic stem cells can differentiate into polarized epithelial cells bearing tight junctions,” The Journal of Cell Biology, vol. 141, no. 2, pp. 397–408, 1998.
- M. Saitou, M. Furuse, H. Sasaki et al., “Complex phenotype of mice lacking occludin, a component of tight junction strands,” Molecular Biology of the Cell, vol. 11, no. 12, pp. 4131–4142, 2000.
- I. Martìn-Padura, S. Lostaglio, M. Schneemann et al., “Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration,” The Journal of Cell Biology, vol. 142, no. 1, pp. 117–127, 1998.
- A. C. Monteiro and C. A. Parkos, “Intracellular mediators of JAM-A-dependent epithelial barrier function,” Annals of the New York Academy of Sciences, vol. 1257, no. 1, pp. 115–124, 2012.
- K. I. Takano, T. Kojima, M. Go et al., “HLA-DR- and CD11c-positive dendritic cells penetrate beyond well-developed epithelial tight junctions in human nasal mucosa of allergic rhinitis,” The Journal of Histochemistry and Cytochemistry, vol. 53, no. 5, pp. 611–619, 2005.
- M. Kurose, T. Kojima, J. I. Koizumi et al., “Induction of claudins in passaged hTERT-transfected human nasal epithelial cells with an extended life span,” Cell and Tissue Research, vol. 330, no. 1, pp. 63–74, 2007.
- J. I. Koizumi, T. Kojima, N. Ogasawara et al., “Protein kinase c enhances tight junction barrier function of human nasal epithelial cells in primary culture by transcriptional regulation,” Molecular Pharmacology, vol. 74, no. 2, pp. 432–442, 2008.
- T. Ohkuni, T. Kojima, N. Ogasawara et al., “Expression and localization of tricellulin in human nasal epithelial cells in vivo and in vitro,” Medical Molecular Morphology, vol. 42, no. 4, pp. 204–211, 2009.
- R. Kamekura, T. Kojima, J. I. Koizumi et al., “Thymic stromal lymphopoietin enhances tight-junction barrier function of human nasal epithelial cells,” Cell and Tissue Research, vol. 338, no. 2, pp. 283–293, 2009.
- N. Ogasawara, T. Kojima, M. Go et al., “PPARγ agonists upregulate the barrier function of tight junctions via a PKC pathway in human nasal epithelial cells,” Pharmacological Research, vol. 61, no. 6, pp. 489–498, 2010.
- T. Ohkuni, T. Kojima, N. Ogasawara et al., “Poly(I:C) reduces expression of JAM-A and induces secretion of IL-8 and TNF-α via distinct NF-κB pathways in human nasal epithelial cells,” Toxicology and Applied Pharmacology, vol. 250, no. 1, pp. 29–38, 2011.
- J. Mach, T. Hshieh, D. Hsieh, N. Grubbs, and A. Chervonsky, “Development of intestinal M cells,” Immunological Reviews, vol. 206, pp. 177–189, 2005.
- A. Gebert, “The role of M cells in the protection of mucosal membranes,” Histochemistry and Cell Biology, vol. 108, no. 6, pp. 455–470, 1997.
- A. M. Clark and B. H. Hirst, “Expression of junction-associated proteins differentiates mouse intestinal M cells from enterocytes,” Histochemistry and Cell Biology, vol. 118, no. 2, pp. 137–147, 2002.
- M. J. P. van Kempen, G. T. Rijkers, and P. B. van Cauwenberge, “The immune response in adenoids and tonsils,” International Archives of Allergy and Immunology, vol. 122, no. 1, pp. 8–19, 2000.
- P. J. Giannasca, J. A. Boden, and T. P. Monath, “Targeted delivery of antigen to hamster nasal lymphoid tissue with M- cell-directed lectins,” Infection and Immunity, vol. 65, no. 10, pp. 4288–4298, 1997.
- T. Kucharzik, N. Lügering, K. W. Schmid, M. A. Schmidt, R. Stoll, and W. Domschke, “Human intestinal M cells exhibit enterocyte-like intermediate filaments,” Gut, vol. 42, no. 1, pp. 54–62, 1998.
- P. Verbrugghe, W. Waelput, B. Dieriks, A. Waeytens, J. Vandesompele, and C. A. Cuvelier, “Murine M cells express annexin V specifically,” Journal of Pathology, vol. 209, no. 2, pp. 240–249, 2006.
- P. Kumar and J. F. Timoney, “Light and electron microscope studies on the nasopharynx and nasopharyngeal tonsil of the horse,” Anatomia, Histologia, Embryologia, vol. 30, no. 2, pp. 77–84, 2001.
- A. Carapelli, M. Regoli, C. Nicoletti, L. Ermini, L. Fonzi, and E. Bertelli, “Rabbit tonsil-associated M-cells express cytokeratin 20 and take up particulate antigen,” The Journal of Histochemistry and Cytochemistry, vol. 52, no. 10, pp. 1323–1331, 2004.
- P. Verbrugghe, P. Kujala, W. Waelput, P. J. Peters, and C. A. Cuvelier, “Clusterin in human gut-associated lymphoid tissue, tonsils, and adenoids: localization to M cells and follicular dendritic cells,” Histochemistry and Cell Biology, vol. 129, no. 3, pp. 311–320, 2008.
- J. H. Lee, S. K. Kong, Z. S. Wu et al., “Class II β-tubulin is a novel marker for human tonsillar M cells and follicular dendritic cells,” Journal of Oral Pathology and Medicine, vol. 39, no. 7, pp. 533–539, 2010.
- M. Rescigno, M. Urbano, B. Valzasina et al., “Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria,” Nature Immunology, vol. 2, no. 4, pp. 361–367, 2001.
- S. S. J. Sung, S. M. Fu, C. E. Rose Jr., F. Gaskin, S. T. Ju, and S. R. Beaty, “A major lung CD103 (αE)-β7 integrin-positive epithelial dendritic cell population expressing langerin and tight junction proteins,” The Journal of Immunology, vol. 176, no. 4, pp. 2161–2172, 2006.
- S. C. Zimmerli and C. Hauser, “Langerhans cells and lymph node dendritic cells express the tight junction component claudin-1,” Journal of Investigative Dermatology, vol. 127, no. 10, pp. 2381–2390, 2007.
- N. Ogasawara, T. Kojima, M. Go et al., “Induction of JAM-A during differentiation of human THP-1 dendritic cells,” Biochemical and Biophysical Research Communications, vol. 389, no. 3, pp. 543–549, 2009.
- R. Kamekura, T. Kojima, A. Takashima et al., “Thymic stromal lymphopoietin induces tight junction protein claudin-7 via NF-κB in dendritic cells,” Histochemistry and Cell Biology, vol. 133, no. 3, pp. 339–348, 2010.
- N. Ogasawara, T. Kojima, M. Go et al., “Epithelial barrier and antigen uptake in lymphoepithelium of human adenoids,” Acta Oto-Laryngologica, vol. 131, no. 2, pp. 116–123, 2011.
- A. Iwasaki and R. Medzhitov, “Toll-like receptor control of the adaptive immune responses,” Nature Immunology, vol. 5, no. 10, pp. 987–995, 2004.
- K. Takeda and S. Akira, “Toll-like receptors in innate immunity,” International Immunology, vol. 17, no. 1, pp. 1–14, 2005.
- T. Kawai and S. Akira, “TLR signaling,” Cell Death and Differentiation, vol. 13, no. 5, pp. 816–825, 2006.
- M. J. Lange, J. C. Lasiter, and M. L. Misfeldt, “Toll-like receptors in tonsillar epithelial cells,” International Journal of Pediatric Otorhinolaryngology, vol. 73, no. 4, pp. 613–621, 2009.
- M. J. Lesmeister, M. R. Bothwell, and M. L. Misfeldt, “Toll-like receptor expression in the human nasopharyngeal tonsil (adenoid) and palantine tonsils: a preliminary report,” International Journal of Pediatric Otorhinolaryngology, vol. 70, no. 6, pp. 987–992, 2006.
- L. Alexopoulou, A. C. Holt, R. Medzhitov, and R. A. Flavell, “Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3,” Nature, vol. 413, no. 6857, pp. 732–738, 2001.
- S. T. Holgate, “Epithelium dysfunction in asthma,” Journal of Allergy and Clinical Immunology, vol. 120, no. 6, pp. 1233–1244, 2007.
- V. Soumelis, P. A. Reche, H. Kanzler et al., “Human epithelial cells trigger dendritic cell-mediated allergic inflammation by producing TSLP,” Nature Immunology, vol. 3, no. 7, pp. 673–680, 2002.
- S. Ying, B. O'Connor, J. Ratoff et al., “Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity,” The Journal of Immunology, vol. 174, no. 12, pp. 8183–8190, 2005.
- B. F. Marple, J. A. Stankiewicz, F. M. Baroody et al., “Diagnosis and management of chronic rhinosinusitis in adults,” Postgraduate Medicine, vol. 121, no. 6, pp. 121–139, 2009.
- N. van Bruaene, C. A. Pérez-Novo, T. M. Basinski et al., “T-cell regulation in chronic paranasal sinus disease,” Journal of Allergy and Clinical Immunology, vol. 121, no. 6, pp. 1435.e3–1441.e3, 2008.
- M. B. Soyka, P. Wawrzyniak, T. Eiwegger, et al., “Defective epithelial barrier in chronic rhinosinusitis: the regulation of tight junctions by IFN-γ and IL-4,” Journal of Allergy and Clinical Immunology. In press.
- J. P. Drolet, H. Frangie, J. Guay, O. Hajoui, Q. Hamid, and B. D. Mazer, “B lymphocytes in inflammatory airway diseases,” Clinical and Experimental Allergy, vol. 40, no. 6, pp. 841–849, 2010.
- M. S. Georgy and A. T. Peters, “Nasal polyps,” in Allergy and Asthma Proceedings, vol. 33, chapter 7, supplement 1, pp. 22–23, 2012.
- G. A. Rogers, K. Den Beste, C. A. Parkos, A. Nusrat, J. M. Delgaudio, and S. K. Wise, “Epithelial tight junction alterations in nasal polyposis,” International Forum of Allergy and Rhinology, vol. 1, no. 1, pp. 50–54, 2011.
- J. A. Guttman and B. B. Finlay, “Tight junctions as targets of infectious agents,” Biochimica et Biophysica Acta, vol. 1788, no. 4, pp. 832–841, 2009.
- N. K. Yeo and Y. J. Jang, “Rhinovirus infection-induced alteration of tight junction and adherens junction components in human nasal epithelial cells,” The Laryngoscope, vol. 120, no. 2, pp. 346–352, 2010.
- V. Bitko and S. Barik, “Persistent activation of RelA by respiratory syncytial virus involves protein kinase C, underphosphorylated IκBβ, and sequestration of protein phosphatase 2A by the viral phosphoprotein,” Journal of Virology, vol. 72, no. 7, pp. 5610–5618, 1998.
- T. Masaki, T. Kojima, T. Okabayashi et al., “A nuclear factor-κB signaling pathway via protein kinase C δ regulates replication of respiratory syncytial virus in polarized normal human nasal epithelial cells,” Molecular Biology of the Cell, vol. 22, no. 13, pp. 2144–2156, 2011.
- N. Sonoda, M. Furuse, H. Sasaki et al., “Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction strands: evidence for direct involvement of claudins in tight junction barrier,” The Journal of Cell Biology, vol. 147, no. 1, pp. 195–204, 1999.
- K. Matsuhisa, M. Kondoh, H. Suzuki, and K. Yagi, “Comparison of mucosal absorption-enhancing activity between a claudin-3/-4 binder and a broadly specific claudin binder,” vol. 423, no. 2, pp. 229–233, 2012.
- J. Wang, M. Lopez-Fraga, A. Rynko, and D. D. Lo, “TNFR and LTβR agonists induce follicle-associated epithelium and M cell specific genes in rat and human intestinal epithelial cells,” Cytokine, vol. 47, no. 1, pp. 69–76, 2009.
- T. E. Rajapaksa, M. Stover-Hamer, X. Fernandez, H. A. Eckelhoefer, and D. D. Lo, “Claudin 4-targeted protein incorporated into PLGA nanoparticles can mediate M cell targeted delivery,” Journal of Controlled Release, vol. 142, no. 2, pp. 196–205, 2010.
- A. Kubo, K. Nagao, M. Yokouchi, H. Sasaki, and M. Amagai, “External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers,” Journal of Experimental Medicine, vol. 206, no. 13, pp. 2937–2946, 2009.
- M. Fukumatsu, M. Ogawa, S. Arakawa et al., “Shigella targets epithelial tricellular junctions and uses a noncanonical clathrin-dependent endocytic pathway to spread between cells,” Cell Host and Microbe, vol. 11, no. 4, pp. 325–336, 2012.