Table 1: Changes of tight junction proteins and barrier function in HNECs in vitro.

TreatmentsTight junction proteinsBarrier function

FBSCLDN-1↑; CLDN-4↑Upregulation
Growth factorTGF- CLDN-4↑No change
PKC activatorTPACLDN-1↑; OCDN↑; ZO-1↑; ZO-2↑Upregulation
PPAR ligandsRosiglitazone
Troglitazone
CLDN-1↑; CLDN-4↑; OCDN↑; TRIC↑
CLDN-1↑; CLDN-4↑; OCDN↑
Upregulation
TLR3 ligandPoly I:CJAM-ANo change
CytokineTSLPCLDN-1↑; CLDN-4↑; CLDN-7↑; OCDN↑Upregulation
VirusRSVCLDN-4↑; OCDN↑Upregulation