| | Treatments | Tight junction proteins | Barrier function |
| | FBS | CLDN-1↑; CLDN-4↑ | Upregulation | | Growth factor | TGF- | CLDN-4↑ | No change | | PKC activator | TPA | CLDN-1↑; OCDN↑; ZO-1↑; ZO-2↑ | Upregulation | | PPAR ligands | Rosiglitazone
Troglitazone | CLDN-1↑; CLDN-4↑; OCDN↑; TRIC↑
CLDN-1↑; CLDN-4↑; OCDN↑ | Upregulation | | TLR3 ligand | Poly I:C | JAM-A↓ | No change | | Cytokine | TSLP | CLDN-1↑; CLDN-4↑; CLDN-7↑; OCDN↑ | Upregulation | | Virus | RSV | CLDN-4↑; OCDN↑ | Upregulation |
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