About this Journal Submit a Manuscript Table of Contents
BioMed Research International
Volume 2013 (2013), Article ID 953520, 6 pages
http://dx.doi.org/10.1155/2013/953520
Research Article

Effects of Nigella sativa and Lepidium sativum on Cyclosporine Pharmacokinetics

1Department of Pharmaceutics, College of Pharmacy, King Saud University Riyadh, P.O. Box 2457, Riyadh 11451, Saudi Arabia
2Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University Riyadh, Riyadh 11451, Saudi Arabia
3Department of Clinical Pharmacy, College of Pharmacy, King Saud University Riyadh, Riyadh 11451, Saudi Arabia
4Department of Pharmacology, College of Pharmacy, King Saud University Riyadh, Riyadh 11451, Saudi Arabia

Received 4 April 2013; Revised 3 June 2013; Accepted 18 June 2013

Academic Editor: Shigeru Satoh

Copyright © 2013 F. I. Al-Jenoobi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. V. A. Bhattaram, U. Graefe, C. Kohlert, M. Veit, and H. Derendorf, “Pharmacokinetics and bioavailability of herbal medicinal products,” Phytomedicine, vol. 9, supplement 3, pp. 1–33, 2002. View at Publisher · View at Google Scholar · View at Scopus
  2. P. K. Mukherjee and A. Wahile, “Integrated approaches towards drug development from Ayurveda and other Indian system of medicines,” Journal of Ethnopharmacology, vol. 103, no. 1, pp. 25–35, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. S. Shi and U. Klotz, “Drug interactions with herbal medicines,” Clinical Pharmacokinetics, vol. 51, no. 2, pp. 77–104, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. C. Tarirai, A. M. Viljoen, and J. H. Hamman, “Herb-drug pharmacokinetic interactions reviewed,” Expert Opinion on Drug Metabolism and Toxicology, vol. 6, no. 12, pp. 1515–1538, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. Z.-Z. Fang, Y.-Y. Zhang, G.-B. Ge et al., “Identification of cytochrome P450 (CYP) isoforms involved in the metabolism of corynoline, and assessment of its herb-drug interactions,” Phytotherapy Research, vol. 25, no. 2, pp. 256–263, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. Y.-L. Han, H.-L. Yu, D. Li et al., “In vitro inhibition of huanglian [Rhizoma coptidis (L.)] and its six active alkaloids on six cytochrome P450 isoforms in human liver microsomes,” Phytotherapy Research, vol. 25, no. 11, pp. 1660–1665, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. S. H. Y. Ho, M. Singh, A. C. Holloway, and D. J. Crankshaw, “The effects of commercial preparations of herbal supplements commonly used by women on the biotransformation of fluorogenic substrates by human cytochromes P450,” Phytotherapy Research, vol. 25, no. 7, pp. 983–989, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. J. Doehmer and J. Eisenbraun, “Assessment of extracts from mistletoe (Viscum album) for herb-drug interaction by inhibition and induction of cytochrome P450 activities,” Phytotherapy Research, vol. 26, no. 1, pp. 11–17, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. J. Boullata, “Natural health product interactions with medication,” Nutrition in Clinical Practice, vol. 20, no. 1, pp. 33–51, 2005. View at Scopus
  10. A. A. Izzo and E. Ernst, “Interactions between herbal medicines and prescribed drugs: a systematic review,” Drugs, vol. 61, no. 15, pp. 2163–2175, 2001. View at Scopus
  11. D. Faulds, K. L. Goa, and P. Benfield, “Cyclosporin: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in immunoregulatory disorders,” Drugs, vol. 45, no. 6, pp. 953–1040, 1993. View at Scopus
  12. S. Noble and A. Markham, “Cyclosporin: a review of the pharmacokinetic properties, clinical efficacy and tolerability of a microemulsion-based formulation (Neoral),” Drugs, vol. 50, no. 5, pp. 924–941, 1995. View at Scopus
  13. T. Kajita, Y. Higashi, M. Imamura et al., “Effect of imatinib mesilate on the disposition kinetics of ciclosporin in rats,” Journal of Pharmacy and Pharmacology, vol. 58, no. 7, pp. 997–1000, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. X. P. Xue, X. L. Qin, C. Xu et al., “Effect of Wuzhi tablet (Schisandra sphenanthera extract) on the pharmacokinetics of cyclosporine A in rats,” Phytotherapy Research, 2012. View at Publisher · View at Google Scholar
  15. S.-L. Hsiu, Y.-C. Hou, Y.-H. Wang, C.-W. Tsao, S.-F. Su, and P.-D. L. Chao, “Quercetin significantly decreased cyclosporin oral bioavailability in pigs and rats,” Life Sciences, vol. 72, no. 3, pp. 227–235, 2002. View at Publisher · View at Google Scholar · View at Scopus
  16. T. Yokooji, M. Kida, M. Mori et al., “Interaction of Rhei Rhizoma extract with cytochrome P450 3A and efflux transporters in rats,” Die Pharmazie, vol. 65, no. 5, pp. 367–374, 2010. View at Scopus
  17. H.-M. Chiang, P.-D. L. Chao, S.-L. Hsiu, K.-C. Wen, S.-Y. Tsai, and Y.-C. Hou, “Ginger significantly decreased the oral bioavailability of cyclosporine in rats,” American Journal of Chinese Medicine, vol. 34, no. 5, pp. 845–855, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. C. Y. Yang, P. D. L. Chao, Y. C. Hou, S. Y. Tsai, K. C. Wen, and S. L. Hsiu, “Marked decrease of cyclosporin bioavailability caused by coadministration of ginkgo and onion in rats,” Food and Chemical Toxicology, vol. 44, no. 9, pp. 1572–1578, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. H. Gali-Muhtasib, A. Roessner, and R. Schneider-Stock, “Thymoquinone: a promising anti-cancer drug from natural sources,” International Journal of Biochemistry and Cell Biology, vol. 38, no. 8, pp. 1249–1253, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Khader, N. Bresgen, and P. M. Eckl, “In vitro toxicological properties of thymoquinone,” Food and Chemical Toxicology, vol. 47, no. 1, pp. 129–133, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. T. A. Gheita and S. A. Kenawy, “Effectiveness of Nigella sativa oil in the management of rheumatoid arthritis patients: a placebo controlled study,” Phytotherapy Research, vol. 26, no. 8, pp. 1246–1248, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. A. H. Gilani, N. U. Rehman, M. H. Mehmood, and K. M. Alkharfy, “Species differences in the antidiarrheal and antispasmodic activities of Lepidium sativum and insight into underlying mechanisms,” Phytotherapy Research, 2012. View at Publisher · View at Google Scholar
  23. N.-U. Rehman, A.-U. Khan, K. M. Alkharfy, and A.-H. Gilani, “Pharmacological basis for the medicinal use of Lepidium sativum in airways disorders,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 596524, 8 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. S. B. Vohora and M. S. Y. Khan, “Pharmacological studies on Lepidium sativum, Linn,” Indian Journal of Physiology and Pharmacology, vol. 21, no. 2, pp. 118–120, 1977. View at Scopus
  25. P. A. G. M. de Smet, “The role of plant-derived drugs and herbal medicines in healthcare,” Drugs, vol. 54, no. 6, pp. 801–840, 1997. View at Scopus
  26. J. Grenier, C. Fradette, G. Morelli, G. J. Merritt, M. Vranderick, and M. P. Ducharme, “Pomelo juice, but not cranberry juice, affects the pharmacokinetics of cyclosporine in humans,” Clinical Pharmacology and Therapeutics, vol. 79, no. 3, pp. 255–262, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. M.-Y. Lai, S.-L. Hsiu, Y.-C. Hou, S.-Y. Tsai, and P.-D. L. Chao, “Significant decrease of cyclosporine bioavailability in rats caused by a decoction of the roots of Scutellaria baicalensis,” Planta Medica, vol. 70, no. 2, pp. 132–137, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. S. Hedayati, A. Bernareggi, and M. Rowland, “Absorption kinetics of cyclosporin in the rat,” Journal of Pharmacy and Pharmacology, vol. 44, no. 2, pp. 122–124, 1992. View at Scopus
  29. K. S. Lown, J. C. Kolars, K. E. Thummel et al., “Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel,” Drug Metabolism and Disposition, vol. 22, pp. 947–955, 1994.
  30. A. Fahr, “Cyclosporin clinical pharmacokinetics,” Clinical Pharmacokinetics, vol. 24, no. 6, pp. 472–495, 1993. View at Scopus
  31. R. D. Whalen, P. N. V. Tata, G. J. Burckart, and R. Venkataramanan, “Species differences in the hepatic and intestinal metabolism of cyclosporine,” Xenobiotica, vol. 29, no. 1, pp. 3–9, 1999. View at Publisher · View at Google Scholar · View at Scopus
  32. R. Venkataramanan, C. P. Wang, K. Habucky et al., “Species-specific cyclosporine metabolism,” Transplantation Proceedings, vol. 20, no. 2, pp. 680–683, 1988. View at Scopus