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BioMed Research International
Volume 2013 (2013), Article ID 960101, 6 pages
http://dx.doi.org/10.1155/2013/960101
Clinical Study

The Predictive Value of Adrenomedullin for Development of Severe Sepsis and Septic Shock in Emergency Department

Emergency Department of Beijing Chao-Yang Hospital, Affiliated to Capital Medical University, Chaoyang District, Beijing 100020, China

Received 7 April 2013; Accepted 9 July 2013

Academic Editor: Fausto Catena

Copyright © 2013 Yun-Xia Chen and Chun-Sheng Li. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J.-L. Vincent, Y. Sakr, C. L. Sprung et al., “Sepsis in European intensive care units: results of the SOAP study,” Critical Care Medicine, vol. 34, no. 2, pp. 344–353, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. K. Kitamura, K. Kangawa, M. Kawamoto et al., “Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma,” Biochemical and Biophysical Research Communications, vol. 192, no. 2, pp. 553–560, 1993. View at Publisher · View at Google Scholar · View at Scopus
  3. D. C. Bunton, M. C. Petrie, C. Hillier, F. Johnston, and J. J. V. McMurray, “The clinical relevance of adrenomedullin: a promising profile?” Pharmacology and Therapeutics, vol. 103, no. 3, pp. 179–201, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. S. Ueda, K. Nishio, N. Minamino et al., “Increased plasma levels of adrenomedullin in patients with systemic inflammatory response syndrome,” American Journal of Respiratory and Critical Care Medicine, vol. 160, no. 1, pp. 132–136, 1999. View at Scopus
  5. Y. Hirata, C. Mitaka, K. Sato et al., “Increased circulating adrenomedullin, a novel vasodilatory peptide, in sepsis,” Journal of Clinical Endocrinology and Metabolism, vol. 81, no. 4, pp. 1449–1453, 1996. View at Publisher · View at Google Scholar · View at Scopus
  6. K. Nishio, Y. Akai, Y. Murao et al., “Increased plasma concentrations of adrenomedullin correlate with relaxation of vascular tone in patients with septic shock,” Critical Care Medicine, vol. 25, no. 6, pp. 953–957, 1997. View at Publisher · View at Google Scholar · View at Scopus
  7. N. Nagata, J. Kato, K. Kitamura et al., “Increased adrenomedullin concentration in cerebrospinal fluid in patients with septic shock,” Journal of Medicine, vol. 34, no. 1–6, pp. 59–66, 2003. View at Scopus
  8. M. M. Levy, M. P. Fink, J. C. Marshall et al., “2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference,” Intensive Care Medicine, vol. 29, no. 4, pp. 530–538, 2003. View at Scopus
  9. M. Christ-Crain, N. G. Morgenthaler, J. Struck, S. Harbarth, A. Bergmann, and B. Müller, “Mid-regional pro-adrenomedullin as a prognostic marker in sepsis: an observational study,” Critical Care, vol. 9, no. 6, pp. R816–824, 2005. View at Scopus
  10. P. Schuetz, M. Christ-Crain, N. G. Morgenthaler, J. Struck, A. Bergmann, and B. Müller, “Circulating precursor levels of endothelin-1 and adrenomedullin, two endothelium-derived, counteracting substances, in sepsis,” Endothelium, vol. 14, no. 6, pp. 345–351, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. B. Suberviola, Á. Castellanos-Ortega, J. Llorca, F. Ortiz, D. Iglesias, and B. Prieto, “Prognostic value of proadrenomedullin in severe sepsis and septic shock patients with community-acquired pneumonia,” Swiss Medical Weekly, vol. 142, Article ID w13542, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. R.-L. Wang and F.-X. Kang, “Prediction about severity and outcome of sepsis by proatrial natriuretic peptide and pro-adrenomedullin,” Chinese Journal of Traumatology, vol. 13, no. 3, pp. 152–157, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. R. Pezzilli, A. Barassi, A. Pigna et al., “Time course of proadrenomedullin in the early phase of septic shock. A comparative study with other proinflammatory proteins,” Panminerva Medica, vol. 54, no. 3, pp. 211–217, 2012.
  14. P. Wang, M. Zhou, Z. F. Ba, W. G. Cioffi, and I. H. Chaudry, “Up-regulation of a novel potent vasodilatory peptide adrenomedullin during polymicrobial sepsis,” Shock, vol. 10, no. 2, pp. 118–122, 1998. View at Scopus
  15. E. Matsui, K. Kitamura, M. Yoshida et al., “Biosynthesis and secretion of adrenomedullin and proadrenomedullin N-terminal 20 peptide in a rat model of endotoxin shock,” Hypertension Research, vol. 24, no. 5, pp. 543–549, 2001. View at Publisher · View at Google Scholar · View at Scopus
  16. J. Bełtowski and A. Jamroz, “Adrenomedullin—what do we know 10 years since its discovery?” Polish Journal of Pharmacology, vol. 56, no. 1, pp. 5–27, 2004. View at Scopus