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Figure 1: Neuronal density in human hippocampal formation subfields. Neuronal density values from MTLE (black bars), MTLE + D (gray bars), MTLE + P (light gray bars), and from nonepileptic controls (white bars) are indicated as mean ± std. deviation. Asterisks indicate significant statistical difference (double: , single: ) between epileptics and control group. Neuronal loss was observed in granular layer, hilus, CA4, CA1, prosubiculum, and entorhinal cortex. A statistical trend (tr: ) to decreased neuronal density in MTLE + P entorhinal cortex when compared to control can also be seen. Dispersion in the granular layer was greater in epileptic patients than in controls.