Hypoglycemic and Hypolipidemic Potential of a High Fiber Diet in Healthy versus Diabetic Rabbits

Table 2

Pharmacokinetic parameters for insulin obtained on days 14 (healthy rabbits) and 28 (diabetic rabbits) after the administration of an oral 3 g glucose load.

	Day 14 (healthy rabbits)
	Standard chow		Supplemented chow		Standard/supplemented variation
	𝐗  ± SE	CV (%)	𝐗  ± SE	CV (%)
𝑡max (min)	33.33 ± 2.14	29.10	41.67 ± 3.55	36.12
𝐶max (mUI/dL)	18.30 ± 1.82	42.22	13.45 ± 1.39	43.79	↓ 26.5%
AUC (mUI ⋅ min/dL)	1779.7 ± 164.9	39.33	1428.3 ± 141.2	42.08	↓ 19.7%
	Day 28 (mild diabetic rabbits)
	Standard chow		Supplemented chow		Standard/supplemented variation
	𝐗  ± SE	CV (%)	𝐗  ± SE	CV (%)
𝑡max (min)	60.00 ± —	—	60.00 ± —	—
𝐶max (mUI/dL)	2.59 ± 0.51^1	68.08	3.93 ± 0.44	61.82	↑ 50.7%
AUC (mUI ⋅ min/dL)	117.5 ± 20.37^1	66.22	177.1 ± 26.29	58.91	↑ 51.7%
	Day 28 (severe diabetic rabbits)
	Standard chow		Supplemented chow		Standard/supplemented variation
	𝐗  ± SE	CV (%)	𝐗  ± SE	CV (%)
𝑡max (min)	120.00 ± —	—	120.00 ± —	—
𝐶max (mUI/dL)	2.11 ± 0.40	68.08	2.23 ± 0.38	61.82	↑ 5.7%
AUC (mUI ⋅ min/dL)	102.1 ± 19.05	66.22	109.7 ± 20.21	58.91	↑ 7.4%

 ¹Significative differences (𝑡-test, P ≤ 0.05).