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Figure 1: Leukocyte recruitment in the femoral artery of ApoE−/− mice fed HF. (a) Snap-shot microphotographs of the intravital microscopy system (IVM) (left, ×200) and their quantification (right graph) (* , ** ). Arrow heads in microphotographs show adherent leukocytes in the femoral artery. (b) Total cholesterol level and triglyceride level in plasma of ApoE−/− mice fed NC or HF for 2 weeks or 6 weeks (* ). (c) Relative mRNA expression levels of VCAM-1 and ICAM-1 in aortas of wt and ApoE−/− mice (* ). (d) Leukocyte recruitment in following blockade of VCAM-1 by antibody (* ). (e) Microphotograph of the aorta of ApoE−/− mice and wt stained by DHE (×200). (f) mRNA expression of gp91-phox and p22-phox in aorta of ApoE−/− mice (* ).