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BioMed Research International
Volume 2013 (2013), Article ID 962376, 12 pages
http://dx.doi.org/10.1155/2013/962376
Research Article

A Versatile Star PEG Grafting Method for the Generation of Nonfouling and Nonthrombogenic Surfaces

1Laboratory of Endovascular Biomaterials (LBeV), Research Centre, Centre Hospitalier de l’Université de Montreal (CRCHUM), 2099 Alexandre de Sève, Montreal, QC, Canada H2L 2W5
2Department of Mechanical Engineering, École de Technologie Supérieure (ÉTS), 1100 Boulevard Notre-Dame Ouest, Montreal, QC, Canada H3C 1K3
3Department of Engineering Physics, École Polytechnique de Montreal, P.O. Box 6079, Succ. Centre-Ville, Montreal, QC, Canada H3C 3A7
4Laboratory of Thrombosis and Haemostasis Research Centre, Montreal Heart Institute, 5000 Belanger Street, Montreal, QC, Canada H1T 1C8
5Department of Chemical Engineering, École Polytechnique de Montreal, P.O. Box 6079, Succ. Centre-Ville, Montreal, QC, Canada H3C 3A7

Received 25 August 2012; Accepted 16 November 2012

Academic Editor: Fabienne Poncin-Epaillard

Copyright © 2013 Pradeep Kumar Thalla et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Polyethylene glycol (PEG) grafting has a great potential to create nonfouling and nonthrombogenic surfaces, but present techniques lack versatility and stability. The present work aimed to develop a versatile PEG grafting method applicable to most biomaterial surfaces, by taking advantage of novel primary amine-rich plasma-polymerized coatings. Star-shaped PEG covalent binding was studied using static contact angle, X-ray photoelectron spectroscopy (XPS), and quartz crystal microbalance with dissipation monitoring (QCM-D). Fluorescence and QCM-D both confirmed strong reduction of protein adsorption when compared to plasma-polymerized coatings and pristine poly(ethyleneterephthalate) (PET). Moreover, almost no platelet adhesion was observed after 15 min perfusion in whole blood. Altogether, our results suggest that primary amine-rich plasma-polymerized coatings offer a promising stable and versatile method for PEG grafting in order to create nonfouling and nonthrombogenic surfaces and micropatterns.