Review Article

An Insight into the “-Omics” Based Engineering of Streptomycetes for Secondary Metabolite Overproduction

Table 1

List of bioactive compounds produced by streptomycetes.

DrugsStrainsApplications

Aclacinomycin AS. galilaeus Antitumor
ActinorhodinS. coelicolor Antibacterial
AlnumycinStreptomyces sp. CM020Antitumor; gyrase inhibitor; topoisomerase inhibitor
Alpha-lipomycinS. aureofaciens Antibacterial
Amphotericin BS. nodosus Antifungal
ApramycinS. tenebrarius Antibacterial
AranciamycinS. echinatus Antibacterial; Collagenase inhibitor
AscomycinS. hygroscopicus var. ascomyceticus Immunosuppressive; antifungal
AsukamycinS. nodosus subsp. asukaensis Antitumor
AureothinS. thioluteus Antitumor; antifungal; insecticidal
AvermectinS. avermitilis Anthelmintic
BenastatinStreptomyces sp. A2991200Antibacterial; apoptosis inducer; glutathione-S-transferase (GST) inhibitor
BleomycinS.verticillus Antitumor
BorrelidinS. parvulus Tü 4055Angiogenesis inhibitor; antibacterial; antiviral; Antiproliferative
ChalcomycinS. bikiniensis Antibacterial
ChartreusinS. chartreusis Antibacterial; antitumor
ChlorothricinS. antibioticus Antibacterial
ChloramphenicolS. venezuelae Antibacterial
ChromomycinS. griseus Antibacterial; antitumor; antiviral
CoumermycinS. rishiriensis Antibacterial
Concanamycin AS. neyagawaensis Antifungal; antiprotozoal; antitumor; antiviral
Clavulanic acidS. clavuligerus Antibacterial
CosmomycinS. olindensis Antitumor
DaptomycinS. roseosporus Antibacterial
DaunorubicinS. peucetius subsp. caesius Antitumor
DoxorubicinS. peucetius subsp. caesius Antitumor
DunaimycinsS. diastatochromogenes Immunosuppressive
ElloramycinS. olivaceus Antibacterial; antitumor
EnterocinS. maritimus Antibacterial
FormycinS. lavendulae Antitumor
FredericamycinS. griseus; S. chattanoogensis Antibacterial; antifungal; antitumor
FrenolicinS. roseofulvus Antibacterial; antiprotozoal
GilvocarcinS. griseoflavus; S. anandii Antibacterial; antitumor; antiviral
GranaticinS. violaceoruber Antibacterial
Griseorhodin AStreptomyces sp. JP95Antibacterial; human telomerase inhibitor
GeldanamycinS. hygroscopicus Antitumor
GriseusinS. griseus Antibacterial
HalstoctacosanolideS. halstedii Antibacterial
HedamycinS. griseoruber Antitumor
Herbimycin AS. hygroscopicus Antitumor
HerboxidieneS. chromofuscus Herbicidal
Hygromycin BS. hygroscopicus Antibacterial; antifungal
IndanomycinS. antibioticus Antibacterial; antiprotozoal; insecticidal; Ionophore
IstamycinS. tenjimariensis Antibacterial
Jadomycin BS. venezuelae Antibacterial
KanamycinS. kanamyceticus Antibacterial
KirromycinS. collinus Antibacterial
LandomycinS. cyanogenus Antitumor
LasalocidS. lasaliensis Antibacterial
LymphostinStreptomyces sp. KY11783Immunosuppressive
MedermycinStreptomyces sp. AM7161Antibacterial; antitumor
MeilingmycinS. nanchangensis Anthelmintic
MeridamycinS. violaceusniger Neuroprotective
Mitomycin CS. caespitosus Antibacterial; antineoplastic; immunosuppressive
MithramycinS. argillaceus Antibacterial; antitumor
MonensinS. cinnamonensis Antibacterial; ionophore; antiprotozoal
NanchangmycinS. nanchangensis Antibacterial; insecticidal; ionophore
NaphthocyclinoneS. arenae Antibacterial
NeomycinS. faradae Antibacterial
NiddamycinS. caelestis Antibacterial
NeocarzinostatinS. carzinostaticus Antibacteria; antineoplastic
NFAT-133Streptomyces sp. PM324667Antidiabetic
NigericinS. violaceusniger Antibacterial; ionophore
NogalamycinS. nogalater Antibacterial; antitumor
Nikkomycin XS. ansochromogenes Antibacterial
NystatinS. noursei Antifungal
NovobiocinS. niveus Antibacterial
OligomycinS. avermitilis Antifungal
OviedomycinS. antibioticus Antitumor
OxazolomycinS. albus Antibacterial; antitumor; antivirus; ionophore
OxytetracyclineS. rimosus Antibacterial
PactamycinS. pactum Antibacterial; antiprotozoal; antitumor; antiviral
ParomycinS. rimosus Antiamoebal, antibiotics
PhoslactomycinStreptomyces sp. HK803Antitumor
PikromycinS. venezuelae Antibacterial
PimaricinS. natalensis Antifungal
PladienolideS. platensis Antitumor
PristinamycinS. pristinaespiralis Antibacterial
PolyketomycinS. diastatochromogenes Antibacterial; antitumor
PikromycinS. venezuelae Antibacterial
RapamycinS. hygroscopicus Immunosuppressive; antitumor; neuroprotective; antiaging
RibostamycinS. ribosidificus Antibacterial
ResistomycinS. resistomycificus Antibacterial; antiviral
RimocidinS. diastaticus Antifungal
RubradirinS. achromogenes var. rubradiris Antibacterial
Saframycin AS. lavendulae Antitumor
SteffimycinS. steffisburgensis Antitumor
StreptolydiginS. lydicus Antibacterial
SparsomycinS. sparsogenes Antitumor
SpiramycinS. ambofaciens. Antibacterial
SpectinomycinS. spectabilis Antibacterial
StreptomycinS. greseus Antibacterial
TautomycetinStreptomyces sp. CK4412Antifungal; antitumor; immunosuppressive
TautomycinS. spiroverticillatus Antibacterial; antifungal; antitumor
TetronomycinStreptomyces sp. NRRL11266Antibacterial; ionophore
ThiostreptonS. azureus Antibacterial
TetracyclineS. aureofaciens Antibacterial
UrdamycinS. fradiae Antibacterial; antitumor
VicenistatinS. halstedii Antitumor
VirginiamycinS. virginiae Antibacterial