An Insight into the “-Omics” Based Engineering of Streptomycetes for Secondary Metabolite Overproduction

Table 5

Methodologies used to overproduce drugs using engineered transcriptomics approach.

Strains	Drugs	Approach	Methodologies
Streptomycetes	Antibiotics	Engineered Transcriptomics	TetR family transcriptional regulator as a global upregulator for enhanced antibiotic production
S. peucetius OIM	Doxorubicin and Daunorubicin	Engineered Transcriptomics	Disruption of wblA from S. peucetius OIM resulted in increase in the production of both doxorubicin and daunorubicin