Evaluation of In Vivo Wound Healing Activity of Bacopa monniera on Different Wound Model in Rats

Table 1

Effect of BME and VTE on wound contraction, epithelization period, and scar area in excision wound.

Oral treatment; (mg/kg, od)	Wound area in mm^2/rat (% contraction)									Epithelization; period (days)	Scar area; (mm^2)
	0 day	4th day	8th day	12th day	14th day	16th day	18th day	20th day	22nd day
Control 0.5% CMC	532.8 ± 6.93; (0.00)	417.7 ± 6.77; (21.6 ± 1.0)	322.3 ± 10.8; (39.5 ± 1.73)	168.5 ± 10.1; (68.3 ± 2.03)	103.3 ± 5.79; (80.6 ± 1.16)	81.2 ± 2.36; (84.8 ± 0.48)	36.2 ± 1.25; (93.2 ± 0.20)	10.3 ± 0.67; (98.1 ± 0.15)	3.17 ± 0.75; (99.4 ± 0.15)	12.7 ± 0.67	99.8 ± 4.92
BME 25	530.3 ± 7.15; (0.00)	359.2 ± 12.2^b; (32.2 ± 2.71)	217.8 ± 20.8^b; (59.0 ± 3.96)	77.2 ± 5.21^c; (85.4 ± 1.08)	42.0 ± 3.86^c; (92.1 ± 0.72)	22.3 ± 2.33^c; (95.8 ± 0.46)	4.60 ± 0.56^c; (99.0 ± 0.09)	0.0 ± 0.0^c; (100.0)	0.0 ± 0.0^c; (100.0)	10.3 ± 0.49^a	75.2 ± 4.04^b
VTE 200	550.0 ± 7.02; (0.00)	371.7 ± 12.1^b; (32.4 ± 2.03)	229.8 ± 14.2^c; (58.3 ± 2.48)	68.3 ± 2.55^c; (87.6 ± 0.49)	42.8 ± 6.13^c; (92.2 ± 1.12)	19.7 ± 3.02^c; (96.4 ± 0.55)	3.83 ± 0.98^c; (99.3 ± 0.17)	0.0 ± 0.0^c; (100.0)	0.0 ± 0.0^c; (100.0)	10.0 ± 0.58^a	74.3 ± 3.98^b

Values are mean ± SEM (Percent) of 6 rats in each group. ^a𝑃<0.05, ^b𝑃<0.01, and ^c𝑃<0.001 compared to respective day control group (statistical analysis was done by one-way analysis of variance followed by Dunnett’s test for multiple comparisons).