About this Journal Submit a Manuscript Table of Contents
BioMed Research International
Volume 2013 (2013), Article ID 972506, 6 pages
http://dx.doi.org/10.1155/2013/972506
Research Article

Helminth Excreted/Secreted Antigens Repress Expression of LPS-Induced Let-7i but Not miR-146a and miR-155 in Human Dendritic Cells

1Biomedicine Unit, Facultad de Estudios Superiores Iztacala, UNAM, Avenida de los Barrios No. 1 Col. Los Reyes Iztacala, 54090 Tlalnepantla, MEX, Mexico
2Department of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1 Col. Sección XVI, 140080 Tlalpan, DF, Mexico
3Blood Bank, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1 Col. Sección XVI, 140080 Tlalpan, DF, Mexico
4Department of Health Care, Universidad Autónoma Metropolitana Xochimilco, Calzada del Hueso No. 1100 Col. Villa Quietud, 04960 Coyoacán, DF, Mexico

Received 7 August 2012; Accepted 1 October 2012

Academic Editor: Miriam Rodríguez-Sosa

Copyright © 2013 Luis I. Terrazas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

MicroRNAs have emerged as key regulators of immune responses. They influence immune cells' function and probably the outcome of several infections. Currently, it is largely unknown if helminth parasites and their antigens modify host microRNAs expression. The aim of this study was to explore if excreted/secreted antigens of Taenia crassiceps regulate LPS-induced miRNAs expression in human Dendritic Cells. We found that these antigens repressed LPS-let-7i induction but not mir-146a or mir-155 and this correlates with a diminished inflammatory response. This let-7i downregulation in Dendritic Cells constitutes a novel feature of the modulatory activity that helminth-derived antigens exert on their host.