Acute Toxicity and Gastroprotective Role of M. pruriens in Ethanol-Induced Gastric Mucosal Injuries in Rats
Figure 3
Histological effects of M. pruriens on gastric tissue (H&E staining 20x). In the negative control group and the extract control group no injuries to the gastric mucosa are observed ((a) and (b)). The ulcer control group has severe disruption to the surface epithelium (black arrow); necrotic lesions penetrating deeply into the mucosa, extensive edema of the submucosal layer (yellow arrow) and leucocyte infiltration (blue arrow) (c). The reference control group shows mild disruption of the surface epithelium mucosa. There are edema and leucocyte infiltration of the submucosal layer (d). In the experimental groups, rats pretreated with 62.5 mg/kg of the extract show moderate disruption of the surface epithelium with edema and leucocytes infiltration of the submucosal layer (e); in the pretreatment with 125 mg/kg of the extract, rats showed a mild disruption of the surface epithelium with edema and leucocyte infiltration in submucosal layer (f); rats pretreated with 250 shows mild disruption of the surface epithelium with edema and leucocytes infiltration of the submucosal layer (g); pretreatment with 500 mg/kg of the extract showed mild edema and leucocytes infiltration of the submucosal layer but no disruption of the surface epithelium (h).
