Electrical Impedance Spectroscopy as Electrical Biopsy for Monitoring Radiation Sequelae of Intestine in Rats

Table 1

Morphological of assessment for evaluation of radiation injury score (RIS).

Early response
Thickening of serosa
0: None
1: Thickening of serosa; hyperplasia of peritoneal mesothelium
Mucosal ulcerations
0: Small
1: Superficial ulcerations; ulcerations involving more than half of the intestinal circumference
Epithelial atypia
0: None
1: Abnormally oriented crypts; irregular crypt regeneration with atypical epithelial cells
Later esponse
Vascular sclerosis
0: None
1: Thickening and hyalinization of vessel wall; vessel wall double normal thickness; hyalinization and stenosis; sclerosis with stenosis or complete occlusion; fibrinoid necrosis
Intestinal wall fibrosis
0: None
1: Submucosa two to four times normal thickness; broadened and hyalinized collagen fibers; abnormal collagen fibers; massive fibrosis including muscularis