About this Journal Submit a Manuscript Table of Contents
BioMed Research International
Volume 2013 (2013), Article ID 976383, 8 pages
Research Article

Characterization of CD8+ T-Cell Responses in the Peripheral Blood and Skin Injection Sites of Melanoma Patients Treated with mRNA Electroporated Autologous Dendritic Cells (TriMixDC-MEL)

1Laboratory of Molecular and Cellular Therapy, Department of Immunology-Physiology and Dendritic Cell Bank, Vrije Universiteit Brussel, 1090 Brussels, Belgium
2Department of Medical Oncology, Universitair Ziekenhuis Brussel, 1090 Brussels, Belgium

Received 4 June 2012; Accepted 21 July 2012

Academic Editor: Julie Curtsinger

Copyright © 2013 Daphné Benteyn et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [8 citations]

The following is the list of published articles that have cited the current article.

  • Nathalie Kerkhoff, Hetty J. Bontkes, Theresia M. Westers, Tanja D. De Gruijl, Shahram Kordasti, and Arjan A. Van De Loosdrecht, “Dendritic cells in myelodysplastic syndromes: From pathogenesis to immunotherapy,” Immunotherapy, vol. 5, no. 6, pp. 621–637, 2013. View at Publisher · View at Google Scholar
  • Daphne Benteyn, Sebastien Anguille, Sandra Van Lint, Carlo Heirman, An M. T. Van Nuffel, Jurgen Corthals, Sebastian Ochsenreither, Wim Waelput, Katrien Van Beneden, Karine Breckpot, Viggo Van Tendeloo, Kris Thielemans, and Aude Bonehill, “Design of an Optimized Wilms' Tumor 1 (WT1) mRNA Construct for Enhanced WT1 Expression and Improved Immunogenicity In Vitro and In Vivo,” Molecular Therapy-Nucleic Acids, vol. 2, 2013. View at Publisher · View at Google Scholar
  • S. Wilgenhof, A. M. T. Van Nuffel, D. Benteyn, J. Corthals, C. Aerts, C. Heirman, I. Van Riet, A. Bonehill, K. Thielemans, and B. Neyns, “A phase IB study on intravenous synthetic mRNA electroporated dendritic cell immunotherapy in pretreated advanced melanoma patients,” Annals of Oncology, vol. 24, no. 10, pp. 2686–2693, 2013. View at Publisher · View at Google Scholar
  • Daphné Benteyn, Carlo Heirman, Aude Bonehill, Kris Thielemans, and Karine Breckpot, “mRNA-based dendritic cell vaccines,” Expert Review of Vaccines, pp. 1–16, 2014. View at Publisher · View at Google Scholar
  • Yinin Hu, Gina R. Petroni, Walter C. Olson, Andrea Czarkowski, Mark E. Smolkin, William W. Grosh, Kimberly A. Chianese-Bullock, and Craig L. Slingluff, “Immunologic hierarchy, class II MHC promiscuity, and epitope spreading of a melanoma helper peptide vaccine,” Cancer Immunology, Immunotherapy, 2014. View at Publisher · View at Google Scholar
  • Chizuru Ogi, and Atsushi Aruga, “New concepts of biomarkers and clinical outcomes for therapeutic cancer vaccines in clinical trials,” Immunotherapy, vol. 6, no. 10, pp. 1025–1036, 2014. View at Publisher · View at Google Scholar
  • Norma Bloy, Jonathan Pol, Fernando Aranda, Alexander Eggermont, Isabelle Cremer, Wolf Hervé Fridman, Jitka Fučíková, Jérôme Galon, Eric Tartour, Radek Spisek, Madhav V. Dhodapkar, Laurence Zitvogel, Guido Kroemer, and Lorenzo Galluzzi, “Trial Watch: Dendritic cell-based anticancer therapy,” OncoImmunology, pp. 00–00, 2014. View at Publisher · View at Google Scholar
  • Ugur Sahin, Katalin Kariko, and Oezlem Tuereci, “mRNA-based therapeutics - developing a new class of drugs,” Nature Reviews Drug Discovery, vol. 13, no. 10, pp. 759–780, 2014. View at Publisher · View at Google Scholar