981235.fig.001a
(a)
981235.fig.001b
(b)
981235.fig.001c
(c)
981235.fig.001d
(d)
Figure 1: Morphology of the lung tissues of different groups after HE staining. (a) and (b) The lung tissue of the control group (Group A) at 0 and 8 h, respectively, in which the alveolar structures are integral without effusion from inside the alveoli or pulmonary interstitial edema; (c) the lung tissue of the acute lung injury group, in which swollen alveolar epithelia, thickened alveolar walls, telangiectasia and capillary hyperemia, and pulmonary interstitial edema, noticeably increased effusion of inflammatory cells, red blood cells, and proteins from inside the alveoli, and disordered alveolar structures are observed, showing pathological changes of acute lung injury; and (d) the lung tissue of Group C after the administration of the p38MAPK inhibitor SB203580, in which effusion of inflammatory cells, red blood cells, and proteins from inside the alveoli is observed, but the interstitial and alveolar edemata are milder compared with Group B.