Effect of Perilla frutescens Fixed Oil on Experimental Esophagitis in Albino Wistar Rats

Table 2

Effect of Perilla frutescens fixed oil (PFO) on pH, volume of gastric juice, total acidity, esophagitis index, and free acidity on experimental esophagitis in albino rats.

Groups	Treatment	pH	Volume of gastric juices  (mL/100 g)	Total acidity (mEq/L)	Esophagitis index	Free acidity (mEq/L)
Group-I	Sham control (normal saline, 3.0 mL/kg, i.p.)	3.52±0.02	3.65±0.63	68.4±0.95	0.49±0.06	59.9±0.42
Group-II	Toxic control (normal saline, 3 mL/kg, i.p.)	2.66±0.01	6.86±0.65	176.3±0.85	0.82±0.01	165.6±0.52
Group-III	PFO (1 mL/kg, i.p.)	2.79±0.11^c,x	4.95±0.77^b,z; (27.84)	112.7±0.11^c,z; (36.07)	0.76±0.007^c,y; (7.31)	121.0±0.70^c,z; (26.93)
Group-IV	PFO (2 mL/kg, i.p.)	3.32±0.08^c,z	3.06±0.33^z; (55.39)	92.4±0.68^c,z; (47.58)	0.64±0.008^c,z; (21.95)	89.0±0.54^c,z; (46.27)
Group-V	PFO (3 mL/kg, i.p.)	3.75±0.03^c,z	2.22±0.38^b,z; (67.64)	70.3±0.86^b,z; (60.12)	0.53±0.006^a,z; (35.37)	56.0±0.33^c,z; (66.18)
Group-VI	Pantoprazole (30 mg/kg, i.p.)	3.91±0.07^c,z	1.36±0.52^c,z; (80.17)	73.7±0.52^c,z; (58.19)	0.44±0.005^a,z; (46.34)	61.30±0.33^c,z; (62.98)

Each group contains 6 animals. All data were presented as mean ± SD, and values in parenthesis represent percentage inhibition.
Statistical significance compared to control [^a𝑃<0.05, ^b𝑃<0.01, ^c𝑃<0.001] and toxic control [^x𝑃<0.05, ^y𝑃<0.01, ^z𝑃<0.001] using one way ANOVA followed by Bonferroni test.